RGD Reference Report - Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet. - Rat Genome Database

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Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.

Authors: de Sousa, Andressa Rodrigues  de Castro Moreira, Maria Eliza  Toledo, Renata Celi Lopes  Dos Anjos Benjamin, Laércio  Queiroz, Valéria Aparecida Vieira  Veloso, Marcia Paranho  de Souza Reis, Kassius  Martino, Hércia Stampini Duarte 
Citation: de Sousa AR, etal., Food Res Int. 2018 Oct;112:48-55. doi: 10.1016/j.foodres.2018.06.004. Epub 2018 Jun 4.
RGD ID: 25824942
Pubmed: PMID:30131158   (View Abstract at PubMed)
DOI: DOI:10.1016/j.foodres.2018.06.004   (Journal Full-text)

The study investigated the effect of extruded sorghum flour (ESF) in a high fat diet (HFD) on biometric measurements and hepatic lipogenesis. Male Wistar rats were fed a normal diet (AIN-93M), HFD, HFD plus ESF replacing 50% cellulose and 100% corn starch (HFDS50), or HFD plus ESF replacing 100% cellulose and 100% corn starch (HFDS100) for eight weeks. ESF reduced the body mass index and liver weight of obese rats. Additionally, ESF reduced hepatic lipogenesis by increasing adiponectin 2 receptor gene expression and gene and protein expressions of peroxisome proliferator-activated receptor α (PPARα), while reducing the gene expression of sterol regulatory element-binding transcription factor 1. Molecular docking analysis revealed the affinity of ESF compounds (luteolinidin, apigeninidin, 5-methoxy-luteolinidin, and 7-methoxy-apigeninidin) with the PPAR-α receptor. Histological analysis confirmed the decreased grade of hepatic steatosis in obese rats. These data indicate the potential of ESF to reduce metabolic risk of hepatic steatosis associated with lipogenesis and obesity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADIPOR2Humanmetabolic dysfunction-associated steatohepatitis treatmentISOAdipor2 (Rattus norvegicus)associated with obesityRGD 
Adipor2Ratmetabolic dysfunction-associated steatohepatitis treatmentIEP associated with obesityRGD 
Adipor2Mousemetabolic dysfunction-associated steatohepatitis treatmentISOAdipor2 (Rattus norvegicus)associated with obesityRGD 
ADIPOR2Humanobesity treatmentISOAdipor2 (Rattus norvegicus)associated with non-alcoholic fatty liver diseaseRGD 
Adipor2Ratobesity treatmentIEP associated with non-alcoholic fatty liver diseaseRGD 
Adipor2Mouseobesity treatmentISOAdipor2 (Rattus norvegicus)associated with non-alcoholic fatty liver diseaseRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Adipor2Ratresponse to nutrient levels  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipor2  (adiponectin receptor 2)

Genes (Mus musculus)
Adipor2  (adiponectin receptor 2)

Genes (Homo sapiens)
ADIPOR2  (adiponectin receptor 2)


Additional Information