RGD Reference Report - Regulation of dendrite morphology and excitatory synapse formation by zDHHC15. - Rat Genome Database

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Regulation of dendrite morphology and excitatory synapse formation by zDHHC15.

Authors: Shah, Bhavin S  Shimell, Jordan J  Bamji, Shernaz X 
Citation: Shah BS, etal., J Cell Sci. 2019 Jul 5;132(13). pii: jcs.230052. doi: 10.1242/jcs.230052.
RGD ID: 25671406
Pubmed: PMID:31189538   (View Abstract at PubMed)
PMCID: PMC6633394   (View Article at PubMed Central)
DOI: DOI:10.1242/jcs.230052   (Journal Full-text)

Protein palmitoylation is the most common post-translational lipid modification in the brain and is mediated by a family of 24 zDHHC enzymes. There has been growing interest in zDHHCs due to mounting evidence that these enzymes play key roles in the development and function of neuronal connections, and the fact that a number of zDHHCs have been associated with neurodevelopmental and neurodegenerative diseases. Loss-of-function variants in several zDHHCs, including zDHHC15, have been identified in patients with intellectual disabilities; however, the function of zDHHC15 in the brain has not been well studied. Here, we demonstrate that knocking down zDHHC15 in primary rat hippocampal cultures reduces dendritic outgrowth and arborization, as well as spine maturation. Moreover, knockdown of zDHHC15 reduces palmitoylation of PSD-95 and its trafficking into dendrites, resulting in an overall decrease in the density of excitatory synapses being formed onto mutant cells.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Zdhhc15Ratpositive regulation of dendrite development involved_inIMP PMID:31189538UniProt 
Zdhhc15Ratprotein localization to postsynapse involved_inIMP PMID:31189538UniProt 
Zdhhc15Ratregulation of dendritic spine morphogenesis involved_inIMP PMID:31189538UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Zdhhc15RatGolgi membrane located_inIDA PMID:31189538UniProt 
Zdhhc15Ratplasma membrane NOT|located_inIDA PMID:31189538UniProt 
Zdhhc15Ratpostsynapse located_inIDA PMID:31189538UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Zdhhc15  (zinc finger DHHC-type palmitoyltransferase 15)


Additional Information