RGD Reference Report - Sex comparison of heme pathway in rats bearing hepatic tumors. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Sex comparison of heme pathway in rats bearing hepatic tumors.

Authors: Wainstok de Calmanovici, R  Cochón, A C  Aldonatti, C  Cabral, J R  San Martín de Viale, L C 
Citation: Wainstok de Calmanovici R, etal., Tumori. 1991 Oct 31;77(5):379-84.
RGD ID: 25440495
Pubmed: PMID:1781034   (View Abstract at PubMed)

The present study was undertaken to explore the effect of the presence of hepatic tumors induced by diethylinitrosamine (DENA) on the metabolic heme pathway, and to assess whether these tumors can modify the response of rats to the porphyrinogenic drug hexachlorobenzene (HCB) and whether the above mentioned effects occur to a greater extent in females than males. The results obtained showed that: a) Females were more susceptible to the hepatocarcinogenicity of DENA than males. b) Female normal and DENA treated rats were more susceptible than male rats to the porphyrinogenicity of HCB. c) The presence of hepatic DENA induced tumors could diminish basal hepatic ferrochelatase activity. d) Hepatic tumors could modify the response of animals to a porphyrinogenic drug such as HCB. Thus, both female and male DENA/HBC rats accumulated more porphyrins and showed a lower delta-aminolevulinate synthase and uroporphyrinogen I synthase induction than HCB rats. e) The heme pathway was functional in DENA induced tumors in both male and female rats but they were little affected by HCB.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HMBSHumanliver carcinoma sexual_dimorphismISORGD:2801Protein:increased activity:liver (rat)RGD 
HmbsRatliver carcinoma sexual_dimorphismIEP Protein:increased activity:liver (rat)RGD 
HmbsMouseliver carcinoma sexual_dimorphismISORGD:2801Protein:increased activity:liver (rat)RGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HMBSHumanhexachlorobenzene increases activityISORGD:2801Hexachlorobenzene increases activity of Hmbs protein in liverRGD 
HmbsRathexachlorobenzene increases activityEXP Hexachlorobenzene increases activity of Hmbs protein in liverRGD 
HmbsMousehexachlorobenzene increases activityISORGD:2801Hexachlorobenzene increases activity of Hmbs protein in liverRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HmbsRatporphyrin-containing compound biosynthetic process  IDA UroporphyrinRGD 
HmbsRatporphyrin-containing compound metabolic process  IDA UroporphyrinogenRGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HMBSHumanheme biosynthetic pathway   ISORGD:2801 RGD 
HmbsRatheme biosynthetic pathway   IDA  RGD 
HmbsMouseheme biosynthetic pathway   ISORGD:2801 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Hmbs  (hydroxymethylbilane synthase)

Genes (Mus musculus)
Hmbs  (hydroxymethylbilane synthase)

Genes (Homo sapiens)
HMBS  (hydroxymethylbilane synthase)


Additional Information