RGD Reference Report - Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population-based study in China. - Rat Genome Database

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Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population-based study in China.

Authors: Andreotti, G  Chen, J  Gao, YT  Rashid, A  Chang, SC  Shen, MC  Wang, BS  Han, TQ  Zhang, BH  Danforth, KN  Althuis, MD  Hsing, AW 
Citation: Andreotti G, etal., Int J Cancer. 2008 May 15;122(10):2322-9.
RGD ID: 2325763
Pubmed: PMID:18076041   (View Abstract at PubMed)
PMCID: PMC2860727   (View Article at PubMed Central)
DOI: DOI:10.1002/ijc.23307   (Journal Full-text)

Biliary tract cancers, encompassing the gallbladder, extrahepatic bile ducts and ampulla of Vater, are rare but highly fatal malignancies. Gallstones, the predominant risk factor for biliary cancers, are linked with hyperlipidemia. As part of a population-based case-control study conducted in Shanghai, China, we examined the associations of serum lipid levels with biliary stones and cancers. We included 460 biliary cancer cases (264 gallbladder, 141 extrahepatic bile duct, and 55 ampulla of Vater), 981 biliary stone cases and 858 healthy individuals randomly selected from the population. Participants completed an in-person interview and gave overnight fasting blood samples. Participants in the highest quintile of triglycerides (>/=160 mg/dl) had a 1.4-fold risk of biliary stones (95% CI = 1.1-1.9), a 1.9-fold risk of gallbladder cancer (95% CI = 1.3-2.8), and a 4.8-fold risk of bile duct cancer (95% CI = 2.8-8.1), compared to the reference group (third quintile: 90-124 mg/dl). Participants in the lowest quintile of high-density lipoprotein (HDL) (<30 mg/dl) had a 4.2-fold risk of biliary stones (95% CI = 3.0-6.0), an 11.6-fold risk of gallbladder cancer (95% CI = 7.3-18.5), and a 16.8-fold risk of bile duct cancer (95% CI = 9.1-30.9), relative to the reference group (third quintile: 40-49 mg/dl). In addition, total cholesterol, low-density lipoprotein (LDL) and apolipoprotein A (apo A) were inversely associated with biliary stones; whereas low levels as well as high levels of total cholesterol, LDL, apo A and apolipoprotein B (apo B) were associated with excess risks of biliary tract cancers. Our findings support a role for serum lipids in gallstone development and biliary carcinogenesis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
APOBHumanbiliary tract cancer  IEP protein:increased expression:serumRGD 
ApobRatbiliary tract cancer  ISOAPOB (Homo sapiens)protein:increased expression:serumRGD 
ApobMousebiliary tract cancer  ISOAPOB (Homo sapiens)protein:increased expression:serumRGD 
APOBHumancommon bile duct neoplasm  IEP protein:increased expression:serumRGD 
ApobRatcommon bile duct neoplasm  ISOAPOB (Homo sapiens)protein:increased expression:serumRGD 
ApobMousecommon bile duct neoplasm  ISOAPOB (Homo sapiens)protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Apob  (apolipoprotein B)

Genes (Mus musculus)
Apob  (apolipoprotein B)

Genes (Homo sapiens)
APOB  (apolipoprotein B)


Additional Information