RGD Reference Report - Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin beta1 signaling. - Rat Genome Database

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Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin beta1 signaling.

Authors: Michaluk, P  Mikasova, L  Groc, L  Frischknecht, R  Choquet, D  Kaczmarek, L 
Citation: Michaluk P, etal., J Neurosci. 2009 May 6;29(18):6007-12.
RGD ID: 2325331
Pubmed: PMID:19420267   (View Abstract at PubMed)
PMCID: PMC6665240   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.5346-08.2009   (Journal Full-text)

Matrix metalloproteinase-9 (MMP-9) has emerged as a physiological regulator of NMDA receptor (NMDAR)-dependent synaptic plasticity and memory. The pathways by which MMP-9 affects NMDAR signaling remain, however, elusive. Using single quantum dot tracking, we demonstrate that MMP-9 enzymatic activity increases NR1-NMDAR surface trafficking but has no influence on AMPA receptor mobility. The mechanism of MMP-9 action on NMDAR is not mediated by change in overall extracellular matrix structure nor by direct cleavage of NMDAR subunits, but rather through an integrin beta1-dependent pathway. These findings describe a new target pathway for MMP-9 action in key physiological and pathological brain processes.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Itgb1Ratprotein transport within lipid bilayer  IMP positive regulation of NMDAR lateral diffusionRGD 
Mmp9Ratregulation of postsynaptic neurotransmitter receptor diffusion trapping involved_inIDA PMID:19420267SynGO 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Mmp9Ratglutamatergic synapse is_active_inIDA PMID:19420267SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Itgb1  (integrin subunit beta 1)
Mmp9  (matrix metallopeptidase 9)


Additional Information