RGD Reference Report - Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines. - Rat Genome Database

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Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines.

Authors: Balague, C  Gambus, G  Carrato, C  Porchet, N  Aubert, JP  Kim, YS  Real, FX 
Citation: Balague C, etal., Gastroenterology. 1994 Apr;106(4):1054-61.
RGD ID: 2324890
Pubmed: PMID:8143972   (View Abstract at PubMed)

BACKGROUND/AIMS: Neoplastic transformation of epithelial cells is commonly associated with altered synthesis and structure of mucin glycoproteins. The aim of the study was to determine if altered mucin gene expression takes place in pancreas cancer. METHODS: To examine mucin gene expression in normal pancreas and pancreas cancer, antibodies detecting the MUC1, MUC2, MUC5B, and MUC5C apomucins were used in immunohistochemical techniques and complementary DNA probes specific for the MUC1-MUC5 genes were used in Northern blots. RESULTS: MUC1 is the major apomucin expressed in normal pancreas, whereas MUC2-MUC5 are weakly expressed or undetectable. In pancreas cancer tissues and cell lines, increased expression of MUC2, MUC4, and MUC5C is shown. The cytoplasmic expression of MUC2 and MUC5C in tumor cells suggests that these apomucins are underglycosylated and abnormally compartmentalized. CONCLUSIONS: Enhanced expression of MUC2, MUC4, and MUC5C genes is a frequent event in pancreas cancer and may contribute to the alterations in the biochemical structure of pancreas cancer mucins.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MUC4Humancommon bile duct neoplasm  IEP protein:increased expression:pancreasRGD 
MUC5ACHumancommon bile duct neoplasm  IEP protein:altered expression:pancreasRGD 
Muc4Ratcommon bile duct neoplasm  ISOMUC4 (Homo sapiens)protein:increased expression:pancreasRGD 
Muc4Mousecommon bile duct neoplasm  ISOMUC4 (Homo sapiens)protein:increased expression:pancreasRGD 
Muc5acRatcommon bile duct neoplasm  ISOMUC5AC (Homo sapiens)protein:altered expression:pancreasRGD 
Muc5acMousecommon bile duct neoplasm  ISOMUC5AC (Homo sapiens)protein:altered expression:pancreasRGD 

Objects Annotated

Genes (Rattus norvegicus)
Muc4  (mucin 4, cell surface associated)
Muc5ac  (mucin 5AC, oligomeric mucus/gel-forming)

Genes (Mus musculus)
Muc4  (mucin 4)
Muc5ac  (mucin 5, subtypes A and C, tracheobronchial/gastric)

Genes (Homo sapiens)
MUC4  (mucin 4, cell surface associated)
MUC5AC  (mucin 5AC, oligomeric mucus/gel-forming)


Additional Information