RGD Reference Report - Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models. - Rat Genome Database

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Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models.

Authors: Futami, K  Kumagai, E  Makino, H  Sato, A  Takagi, M  Shimamoto, A  Furuichi, Y 
Citation: Futami K, etal., Cancer Sci. 2008 Jun;99(6):1227-36. Epub 2008 Apr 14.
RGD ID: 2317370
Pubmed: PMID:18422747   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1349-7006.2008.00794.x   (Journal Full-text)

Small interfering RNAs (siRNAs) are expected to have a medical application in human therapy as drugs with a high specificity for their molecular target mRNAs. RecQL1 DNA helicase in the human RecQ helicase family participates in DNA repair and recombination pathways in the cell cycle of replication. Silencing the RecQL1 expression by RecQL1-siRNA induces mitotic death in vitro specifically in growing cancer cells. By contrast, the same RecQL1 silencing does not affect the growth of normal cells, emphasizing that RecQL1 helicase is an ideal molecular target for cancer therapy. In this study, we show that local and systemic administration of RecQL1-siRNA mixed with polyethyleneimine polymer or cationic liposomes prevented cancer cell proliferation in vivo in mouse models of cancer without noticeable adverse effects. The results indicate that RecQL1-siRNA in a complex with a cationic polymer is a very promising anticancer drug candidate, and that in particular, RecQL1-siRNA formulated with a cationic liposome has an enormous potential to be used by intravenous injection for therapy specific for liver cancers, including metastasized cancers from the colon and pancreas.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RECQLHumanhepatocellular carcinoma  IMP  RGD 
RECQLHumanhepatocellular carcinoma disease_progressionIEP protein:increased expression:liverRGD 
RecqlRathepatocellular carcinoma disease_progressionISORECQL (Homo sapiens)protein:increased expression:liverRGD 
RecqlMousehepatocellular carcinoma disease_progressionISORECQL (Homo sapiens)protein:increased expression:liverRGD 
RECQLHumanlung cancer  IMP  RGD 
RecqlRatlung cancer  ISORECQL (Homo sapiens) RGD 
RecqlMouselung cancer  ISORECQL (Homo sapiens) RGD 
RECQLHumanpancreatic cancer  IMP  RGD 
RecqlRatpancreatic cancer  ISORECQL (Homo sapiens) RGD 
RecqlMousepancreatic cancer  ISORECQL (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Recql  (RecQ like helicase)

Genes (Mus musculus)
Recql  (RecQ protein-like)

Genes (Homo sapiens)
RECQL  (RecQ like helicase)


Additional Information