RGD Reference Report - Proinsulin by immunochemiluminometric assay for the diagnosis of insulinoma. - Rat Genome Database

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Proinsulin by immunochemiluminometric assay for the diagnosis of insulinoma.

Authors: Kao, PC  Taylor, RL  Service, FJ 
Citation: Kao PC, etal., J Clin Endocrinol Metab. 1994 May;78(5):1048-51.
RGD ID: 2317266
Pubmed: PMID:8175958   (View Abstract at PubMed)
DOI: DOI:10.1210/jcem.78.5.8175958   (Journal Full-text)

We used a newly developed immunochemiluminometric assay of proinsulin to determine its relative utility vis-a-vis C-peptide and insulin for the diagnosis of insulinoma. The evaluation was conducted in 20 consecutive patients with histologically confirmed insulinoma and 22 normal subjects who underwent a prolonged fast according to a standard protocol. Patients with insulinoma fasted to the point of demonstrating Whipple's triad; normal subjects fasted to 72 h. At the end of the prolonged fast, when the glucose value was 2.8 mmol/L or less (50 mg/dL), all three hormones had equal sensitivity (100%) in detecting insulinoma with no overlap with the values of normal subjects. When glucose levels were between 2.8 mmol/L (50 mg/dL) and 3.3 mmol/L (60 mg/dL) at the end of the prolonged fast, proinsulin was better than C-peptide and insulin in the diagnosis of insulinoma. The sensitivity was 90% for proinsulin and 85% for both C-peptide and insulin. Therefore, proinsulin not only is useful for the diagnosis of insulinoma, but it may have greater diagnostic accuracy than C-peptide and insulin.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
INSHumaninsulinoma  IDA protein:altered expression:bloodRGD 
Ins2Ratinsulinoma  ISORGD:731056protein:altered expression:bloodRGD 
Ins2Mouseinsulinoma  ISORGD:731056protein:altered expression:bloodRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ins2  (insulin 2)

Genes (Mus musculus)
Ins2  (insulin II)

Genes (Homo sapiens)
INS  (insulin)


Additional Information