RGD Reference Report - Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats. - Rat Genome Database

RGD Reference Report - Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats. - Rat Genome Database

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General

Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats.
Authors:	Morinaga, H Ohta, T Matsui, K Sasase, T Fukuda, S Ito, M Ueda, M Ishii, Y Miyajima, K Matsushita, M
Citation:	Morinaga H, etal., Exp Diabetes Res. 2009;2009:715057. Epub 2009 Aug 19.
RGD ID:	2314022
Pubmed:	PMID:19696902 (View Abstract at PubMed)
PMCID:	PMC2729098 (View Article at PubMed Central)
DOI:	DOI:10.1155/2009/715057 (Journal Full-text)
Spontaneously Diabetic Torii-fa/fa (SDT fatty) rat is a new model of obese type 2 diabetes. SDT fatty rat exhibits obesity associated with hyperphagia. In this study, SDT fatty rats were subjected to pair-feeding with SDT-+/+ (SDT) rats from 6 to 22 weeks of age. The ratio of visceral fat weight to subcutaneous fat weight (V/S) decreased at 12 weeks of age in the pair-feeding rats. The intraperitoneal fat weight such as epididymal and retroperitoneal fat weight decreased, whereas mesenteric fat weight had no change. Cell size of the epididymal fat in the pair-feeding rats tended to decrease. Glucose oxidation level in epididymal fat in the pair-feeding rats at 12 weeks of age was recovered to a similar level with that in SDT rats. These results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity.

Annotation Click to see Annotation Detail View

Disease Annotations

hyperglycemia (IAGP)

hyperinsulinism (IAGP)

Hypertriglyceridemia (IAGP)

obesity (IAGP)

Phenotype Annotations

Mammalian Phenotype

abnormal adipose tissue amount (IAGP)

decreased adipocyte glucose uptake (IAGP)

increased adiponectin level (IAGP)

increased body weight (IAGP)

increased circulating glucose level (IAGP)

increased circulating insulin level (IAGP)

increased circulating leptin level (IAGP)

increased circulating triglyceride level (IAGP)

increased fat cell size (IAGP)

increased food intake (IAGP)

Objects Annotated

Strains

SDT.Cg-Lepr^fa/Jtt (SDT fatty)

Objects referenced in this article

Strain	SDT/Jcl	null	Rattus norvegicus

Additional Information