RGD Reference Report - Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats. - Rat Genome Database

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Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats.

Authors: Morinaga, H  Ohta, T  Matsui, K  Sasase, T  Fukuda, S  Ito, M  Ueda, M  Ishii, Y  Miyajima, K  Matsushita, M 
Citation: Morinaga H, etal., Exp Diabetes Res. 2009;2009:715057. Epub 2009 Aug 19.
RGD ID: 2314022
Pubmed: PMID:19696902   (View Abstract at PubMed)
PMCID: PMC2729098   (View Article at PubMed Central)
DOI: DOI:10.1155/2009/715057   (Journal Full-text)

Spontaneously Diabetic Torii-fa/fa (SDT fatty) rat is a new model of obese type 2 diabetes. SDT fatty rat exhibits obesity associated with hyperphagia. In this study, SDT fatty rats were subjected to pair-feeding with SDT-+/+ (SDT) rats from 6 to 22 weeks of age. The ratio of visceral fat weight to subcutaneous fat weight (V/S) decreased at 12 weeks of age in the pair-feeding rats. The intraperitoneal fat weight such as epididymal and retroperitoneal fat weight decreased, whereas mesenteric fat weight had no change. Cell size of the epididymal fat in the pair-feeding rats tended to decrease. Glucose oxidation level in epididymal fat in the pair-feeding rats at 12 weeks of age was recovered to a similar level with that in SDT rats. These results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SDT.Cg-Leprfa/JttRathyperglycemia  IAGP compared to SDT ratsRGD 
SDT.Cg-Leprfa/JttRathyperinsulinism  IAGP compared to SDT ratsRGD 
SDT.Cg-Leprfa/JttRatHypertriglyceridemia  IAGP compared to SDT ratsRGD 
SDT.Cg-Leprfa/JttRatobesity MODEL: spontaneousIAGP compared to SDT/Jcl ratsRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SDT.Cg-Leprfa/JttRatabnormal adipose tissue amount  IAGP compared to SDT/Jcl ratsRGD 
SDT.Cg-Leprfa/JttRatdecreased adipocyte glucose uptake  IAGP compared to SDT/Jcl and pair-fed SDT.ZDF-Leprfa/Jtt ratsRGD 
SDT.Cg-Leprfa/JttRatincreased adiponectin level  IAGP compared to SDT ratsRGD 
SDT.Cg-Leprfa/JttRatincreased body weight  IAGP compared to SDT/Jcl and pair-fed SDT.ZDF-Leprfa/Jtt ratsRGD 
SDT.Cg-Leprfa/JttRatincreased circulating glucose level  IAGP compared to SDT ratsRGD 
SDT.Cg-Leprfa/JttRatincreased circulating insulin level  IAGP compared to SDT/Jcl rats and only at young ageRGD 
SDT.Cg-Leprfa/JttRatincreased circulating leptin level  IAGP compared to SDT ratsRGD 
SDT.Cg-Leprfa/JttRatincreased circulating triglyceride level  IAGP compared to SDT ratsRGD 
SDT.Cg-Leprfa/JttRatincreased fat cell size  IAGP compared to SDT/Jcl ratsRGD 
SDT.Cg-Leprfa/JttRatincreased food intake  IAGP compared to SDT/Jcl ratsRGD 
Objects Annotated

Strains
SDT.Cg-Leprfa/Jtt  (SDT fatty)

Objects referenced in this article
Strain SDT/Jcl null Rattus norvegicus

Additional Information