RGD Reference Report - Genetic architecture of tameness in a rat model of animal domestication. - Rat Genome Database

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Genetic architecture of tameness in a rat model of animal domestication.

Authors: Albert, FW  Carlborg, O  Plyusnina, I  Besnier, F  Hedwig, D  Lautenschlager, S  Lorenz, D  McIntosh, J  Neumann, C  Richter, H  Zeising, C  Kozhemyakina, R  Shchepina, O  Kratzsch, J  Trut, L  Teupser, D  Thiery, J  Schoneberg, T  Andersson, L  Paabo, S 
Citation: Albert FW, etal., Genetics. 2009 Jun;182(2):541-54. Epub 2009 Apr 10.
RGD ID: 2313383
Pubmed: PMID:19363126   (View Abstract at PubMed)
PMCID: PMC2691762   (View Article at PubMed Central)
DOI: DOI:10.1534/genetics.109.102186   (Journal Full-text)

A common feature of domestic animals is tameness-i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coat spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased aggression towards humans  IDA 2313383; 2313383; 2313383; 2313383; 2313383 RGD 
increased anxiety-related response  IDA 2313383; 2313383; 2313383; 2313383; 2313383 RGD 
white spotting  IDA 2313383 RGD 
Objects Annotated

Anxrr24  (Anxiety related response QTL 24)
Anxrr25  (Anxiety related response QTL 25)
Anxrr26  (Anxiety related response QTL 26)
Anxrr27  (Anxiety related response QTL 27)
Anxrr28  (Anxiety related response QTL 28)
Coatc1  (Coat color QTL1)

Wild/Nov  (NA)

Additional Information