RGD Reference Report - Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetes. - Rat Genome Database

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Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetes.

Authors: Hayden, MR  Karuparthi, PR  Habibi, J  Lastra, G  Patel, K  Wasekar, C  Manrique, CM  Ozerdem, U  Stas, S  Sowers, JR 
Citation: Hayden MR, etal., Exp Biol Med (Maywood). 2008 Sep;233(9):1109-23. Epub 2008 Jul 18.
RGD ID: 2313359
Pubmed: PMID:18641056   (View Abstract at PubMed)
PMCID: PMC2674965   (View Article at PubMed Central)
DOI: DOI:10.3181/0709-RM-251   (Journal Full-text)

CONTEXT: The transgenic human islet amyloid polypeptide (HIP) rat model of type 2 diabetes mellitus (T2DM) parallels the functional and structural changes in human islets with T2DM. OBJECTIVE: The transmission electron microscope (TEM) was utilized to observe the ultrastructural changes in islet microcirculation. METHODS: Pancreatic tissue from male Sprague Dawley rats (2, 4, 8, 14 months) were used as controls (SDC) and compared to the 2-, 4-, 8- and 14-month-old HIP rat models. RESULTS: The 2-month-old HIP model demonstrated no islet or microcirculation remodeling changes when compared to the SDC models. The 4-month-old HIP model demonstrated significant pericapillary amyloid deposition and diminution of pericyte foot processes as compared to the SDC models. The 8-month-old model demonstrated extensive islet amyloid deposition associated with pericyte and beta-cell apoptosis when compared with SDC. The 14-month-old HIP model demonstrated a marked reduction of beta-cells and intra-islet capillaries with near complete replacement of islets by amyloidoses. Increased cellularity in the region of the islet exocrine interface was noted in the 4- to 14-month-old HIP models as compared to SDC. In contrast to intra-islet capillary rarefaction there was noticeable angiogenesis in the islet exocrine interface. Pericytes seemed to be closely associated with collagenosis, intra-islet adipogenesis and angiogenesis in the islet exocrine interface. CONCLUSION: The above novel findings regarding the microcirculation and pericytes could assist researchers and clinicians in a better morphological understanding of T2DM and lead to new strategies for prevention and treatment of T2DM.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IAPPHumantype 2 diabetes mellitus  IMP  RGD 
IappRattype 2 diabetes mellitus  ISOIAPP (Homo sapiens) RGD 
IappMousetype 2 diabetes mellitus  ISOIAPP (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Iapp  (islet amyloid polypeptide)

Genes (Mus musculus)
Iapp  (islet amyloid polypeptide)

Genes (Homo sapiens)
IAPP  (islet amyloid polypeptide)


Additional Information