RGD Reference Report - Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia.

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Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia.
Authors:	Heptulla, RA Rodriguez, LM Mason, KJ Haymond, MW
Citation:	Heptulla RA, etal., J Clin Endocrinol Metab. 2009 May;94(5):1608-11. Epub 2009 Feb 3.
RGD ID:	2313356
Pubmed:	PMID:19190104 (View Abstract at PubMed)
PMCID:	PMC2684475 (View Article at PubMed Central)
DOI:	DOI:10.1210/jc.2008-2580 (Journal Full-text)
CONTEXT: The purpose of this study was to examine the effect of continuous sc replacement of amylin and insulin for a 24-h period on glucose homeostasis in adolescents with type 1diabetes. METHODS: Thirteen adolescents with type 1 diabetes on insulin pump therapy participated in a randomized, controlled, crossover design study comparing continuous sc insulin monotherapy (part A) vs. continuous sc insulin and pramlintide infusion (part B). In part A, basal and bolus insulin infusion was per prescribed home regimen. In part B, the basal insulin infusion was the same as part A, but prandial insulin boluses were reduced by 20%. Basal and prandial bolus pramlintide were administered simultaneously via another pump. All boluses were given as a dual wave. RESULTS: The study regimen resulted in a 26% reduction in postprandial hyperglycemia as compared to insulin monotherapy (area under the curve, 600 min, 2610 +/- 539 vs. 692 +/- 861 mg/liter . min) (P < 0.008). Glucagon concentrations were suppressed postprandially (P < 0.003) but not in the postabsorptive state, whereas plasma insulin concentrations were unchanged. CONCLUSIONS: Simultaneous continuous sc pramlintide and insulin infusion has the potential of improving glucose concentrations by way of physiological replacement.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
IAPP	Human	type 1 diabetes mellitus		IDA			RGD
Iapp	Rat	type 1 diabetes mellitus		ISO	IAPP (Homo sapiens)		RGD
Iapp	Mouse	type 1 diabetes mellitus		ISO	IAPP (Homo sapiens)		RGD

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Genes (Rattus norvegicus)

Iapp (islet amyloid polypeptide)

Genes (Mus musculus)

Iapp (islet amyloid polypeptide)

Genes (Homo sapiens)

IAPP (islet amyloid polypeptide)

Objects referenced in this article

Gene	GFPT1	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens
Gene	Gfpt1	glutamine fructose-6-phosphate transaminase 1	Mus musculus
Gene	Gfpt1	glutamine fructose-6-phosphate transaminase 1	Rattus norvegicus

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Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia.