RGD Reference Report - Genetic regulation of bone traits is influenced by sex and reciprocal cross in F(2) progeny from GK and F344 rats. - Rat Genome Database

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Genetic regulation of bone traits is influenced by sex and reciprocal cross in F(2) progeny from GK and F344 rats.

Authors: Lagerholm, S  Li, LS  Jiao, H  Park, HB  Ohlsson, C  Akesson, K  Luthman, H 
Citation: Lagerholm S, etal., J Bone Miner Res. 2009 Jun;24(6):1066-74.
RGD ID: 2312767
Pubmed: PMID:19113924   (View Abstract at PubMed)
DOI: DOI:10.1359/jbmr.081252   (Journal Full-text)

A genome-wide linkage analysis to identify quantitative trait loci (QTLs) for bone phenotypes was performed in an F(2) intercross of inbred spontaneously type 2 diabetic GK and normoglycemic F344 rats (108 males and 98 females). The aim of the study was to locate genome regions with candidate genes affecting trabecular and cortical bone and to investigate the effects of sex and reciprocal cross. pQCT was used to determine tibial bone phenotypes in the F(2) rats, comprising reciprocal crosses with divergent mitochondrial (mt) DNA. Sex and reciprocal cross-separated QTL analyses were performed followed by assessment of specific interactions. Four genome-wide significant QTLs linked to either cortical vBMD, tibia length, body length, or metaphyseal area were identified in males on chromosomes (chr) 1, 8, and 15. In females, three significant QTLs linked to cortical BMC or metaphyseal total vBMD were identified on chr 1 and 2. Several additional suggestive loci for trabecular and cortical traits were detected in both males and females. Four female-specific QTLs on chr 2, 3, 5, and 10 and four reciprocal cross-specific QTLs on chr 1, 10, and 18 were identified, suggesting that both sex and mt genotype influence the expression of bone phenotypes.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bmd69Ratosteoporosis  IAGP  RGD 
Bmd70Ratosteoporosis  IAGP  RGD 
Bmd71Ratosteoporosis  IAGP  RGD 
Bmd72Ratosteoporosis  IAGP  RGD 
Bmd73Ratosteoporosis  IAGP  RGD 
Bmd74Ratosteoporosis  IAGP  RGD 
Bmd75Ratosteoporosis  IAGP  RGD 
Bmd76Ratosteoporosis  IAGP  RGD 
Bmd77Ratosteoporosis  IAGP  RGD 
Bmd78Ratosteoporosis  IAGP  RGD 
Bmd79Ratosteoporosis  IAGP  RGD 
Bmd80Ratosteoporosis  IAGP  RGD 
Bss51Ratosteoporosis  IAGP  RGD 
Bss52Ratosteoporosis  IAGP  RGD 
Bss53Ratosteoporosis  IAGP  RGD 
Bss54Ratosteoporosis  IAGP  RGD 
Bss55Ratosteoporosis  IAGP  RGD 
Bss56Ratosteoporosis  IAGP  RGD 
Bss57Ratosteoporosis  IAGP  RGD 
Bss58Ratosteoporosis  IAGP  RGD 
Bss59Ratosteoporosis  IAGP  RGD 
Bss60Ratosteoporosis  IAGP  RGD 
Bss61Ratosteoporosis  IAGP  RGD 
Bss62Ratosteoporosis  IAGP  RGD 
Bss63Ratosteoporosis  IAGP  RGD 
Bss64Ratosteoporosis  IAGP  RGD 
Bss65Ratosteoporosis  IAGP  RGD 
Bss66Ratosteoporosis  IAGP  RGD 
Bss67Ratosteoporosis  IAGP  RGD 
Bss68Ratosteoporosis  IAGP  RGD 
Bss69Ratosteoporosis  IAGP  RGD 
Bss70Ratosteoporosis  IAGP  RGD 
Bss71Ratosteoporosis  IAGP  RGD 
Bss72Ratosteoporosis  IAGP  RGD 
Bss73Ratosteoporosis  IAGP  RGD 
Bss74Ratosteoporosis  IAGP  RGD 
Bss75Ratosteoporosis  IAGP  RGD 
Bss76Ratosteoporosis  IAGP  RGD 
Bss77Ratosteoporosis  IAGP  RGD 
Bss78Ratosteoporosis  IAGP  RGD 
Bss79Ratosteoporosis  IAGP  RGD 
Bss80Ratosteoporosis  IAGP  RGD 
Bss81Ratosteoporosis  IAGP  RGD 
Bss82Ratosteoporosis  IAGP  RGD 
Bss83Ratosteoporosis  IAGP  RGD 
Bss84Ratosteoporosis  IAGP  RGD 
Bss85Ratosteoporosis  IAGP  RGD 
Bw96Ratosteoporosis  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bss51Ratdecreased bone mass  IDA  RGD 
Bss52Ratdecreased bone mass  IDA  RGD 
Bss53Ratdecreased bone mass  IDA  RGD 
Bss54Ratdecreased bone mass  IDA  RGD 
Bss55Ratdecreased bone mass  IDA  RGD 
Bss56Ratdecreased bone mass  IDA  RGD 
Bss57Ratdecreased bone mass  IDA  RGD 
Bss58Ratdecreased bone mass  IDA  RGD 
Bss59Ratdecreased bone mass  IDA  RGD 
Bss60Ratdecreased bone mass  IDA  RGD 
Bss61Ratdecreased bone mass  IDA  RGD 
Bss62Ratdecreased bone mass  IDA  RGD 
Bss63Ratdecreased bone mass  IDA  RGD 
Bss64Ratdecreased bone mass  IDA  RGD 
Bss65Ratdecreased bone mass  IDA  RGD 
Bss66Ratdecreased bone mass  IDA  RGD 
Bss67Ratdecreased bone mass  IDA  RGD 
Bss68Ratdecreased bone mass  IDA  RGD 
Bss69Ratdecreased bone mass  IDA  RGD 
Bss70Ratdecreased bone mass  IDA  RGD 
Bss71Ratdecreased bone mass  IDA  RGD 
Bss72Ratdecreased bone mass  IDA  RGD 
Bss73Ratdecreased bone mass  IDA  RGD 
Bss74Ratdecreased bone mass  IDA  RGD 
Bss75Ratdecreased bone mass  IDA  RGD 
Bss76Ratdecreased bone mass  IDA  RGD 
Bss77Ratdecreased bone mass  IDA  RGD 
Bss78Ratdecreased bone mass  IDA  RGD 
Bss79Ratdecreased bone mass  IDA  RGD 
Bss80Ratdecreased bone mass  IDA  RGD 
Bss81Ratdecreased bone mass  IDA  RGD 
Bss82Ratdecreased bone mass  IDA  RGD 
Bss83Ratdecreased bone mass  IDA  RGD 
Bss84Ratdecreased bone mass  IDA  RGD 
Bss85Ratdecreased bone mass  IDA  RGD 
Bmd69Ratdecreased bone mineral density  IDA as compared to femalesRGD 
Bmd70Ratdecreased bone mineral density  IDA as compared to femalesRGD 
Bmd71Ratdecreased bone mineral density  IDA as compared to femalesRGD 
Bss70Ratdecreased bone mineral density  IDA as compared to femalesRGD 
Bss71Ratdecreased bone mineral density  IDA as compared to femalesRGD 
Bss51Ratdecreased bone strength  IDA  RGD 
Bss52Ratdecreased bone strength  IDA  RGD 
Bss53Ratdecreased bone strength  IDA  RGD 
Bss54Ratdecreased bone strength  IDA  RGD 
Bss55Ratdecreased bone strength  IDA  RGD 
Bss56Ratdecreased bone strength  IDA  RGD 
Bss57Ratdecreased bone strength  IDA  RGD 
Bss58Ratdecreased bone strength  IDA  RGD 
Bss59Ratdecreased bone strength  IDA  RGD 
Bss60Ratdecreased bone strength  IDA  RGD 
Bss61Ratdecreased bone strength  IDA  RGD 
Bss62Ratdecreased bone strength  IDA  RGD 
Bss63Ratdecreased bone strength  IDA  RGD 
Bss64Ratdecreased bone strength  IDA  RGD 
Bss65Ratdecreased bone strength  IDA  RGD 
Bss66Ratdecreased bone strength  IDA  RGD 
Bss67Ratdecreased bone strength  IDA  RGD 
Bss68Ratdecreased bone strength  IDA  RGD 
Bss69Ratdecreased bone strength  IDA  RGD 
Bss70Ratdecreased bone strength  IDA  RGD 
Bss71Ratdecreased bone strength  IDA  RGD 
Bss72Ratdecreased bone strength  IDA  RGD 
Bss73Ratdecreased bone strength  IDA  RGD 
Bss74Ratdecreased bone strength  IDA  RGD 
Bss75Ratdecreased bone strength  IDA  RGD 
Bss76Ratdecreased bone strength  IDA  RGD 
Bss77Ratdecreased bone strength  IDA  RGD 
Bss78Ratdecreased bone strength  IDA  RGD 
Bss79Ratdecreased bone strength  IDA  RGD 
Bss80Ratdecreased bone strength  IDA  RGD 
Bss81Ratdecreased bone strength  IDA  RGD 
Bss82Ratdecreased bone strength  IDA  RGD 
Bss83Ratdecreased bone strength  IDA  RGD 
Bss84Ratdecreased bone strength  IDA  RGD 
Bss85Ratdecreased bone strength  IDA  RGD 
Bmd72Ratincreased bone mineral density  IDA as compared to malesRGD 
Bmd73Ratincreased bone mineral density  IDA as compared to malesRGD 
Bmd74Ratincreased bone mineral density  IDA as compared to malesRGD 
Bmd75Ratincreased bone mineral density  IDA as compared to malesRGD 
Bmd76Ratincreased bone mineral density  IDA as compared to malesRGD 
Bmd77Ratincreased bone mineral density  IDA as compared to malesRGD 
Bmd78Ratincreased bone mineral density  IDA as compared to malesRGD 
Bmd79Ratincreased bone mineral density  IDA as compared to malesRGD 
Bmd80Ratincreased bone mineral density  IDA as compared to malesRGD 
Bw96Ratincreased bone mineral density  IDA as compared to malesRGD 
Objects Annotated

QTLs
Bmd69  (Bone mineral density QTL 69)
Bmd70  (Bone mineral density QTL 70)
Bmd71  (Bone mineral density QTL 71)
Bmd72  (Bone mineral density QTL 72)
Bmd73  (Bone mineral density QTL 73)
Bmd74  (Bone mineral density QTL 74)
Bmd75  (Bone mineral density QTL 75)
Bmd76  (Bone mineral density QTL 76)
Bmd77  (Bone mineral density QTL 77)
Bmd78  (Bone mineral density QTL 78)
Bmd79  (Bone mineral density QTL 79)
Bmd80  (Bone mineral density QTL 80)
Bss51  (Bone structure and strength QTL 51)
Bss52  (Bone structure and strength QTL 52)
Bss53  (Bone structure and strength QTL 53)
Bss54  (Bone structure and strength QTL 54)
Bss55  (Bone structure and strength QTL 55)
Bss56  (Bone structure and strength QTL 56)
Bss57  (Bone structure and strength QTL 57)
Bss58  (Bone structure and strength QTL 58)
Bss59  (Bone structure and strength QTL 59)
Bss60  (Bone structure and strength QTL 60)
Bss61  (Bone structure and strength QTL 61)
Bss62  (Bone structure and strength QTL 62)
Bss63  (Bone structure and strength QTL 63)
Bss64  (Bone structure and strength QTL 64)
Bss65  (Bone structure and strength QTL 65)
Bss66  (Bone structure and strength QTL 66)
Bss67  (Bone structure and strength QTL 67)
Bss68  (Bone structure and strength QTL 68)
Bss69  (Bone structure and strength QTL 69)
Bss70  (Bone structure and strength QTL 70)
Bss71  (Bone structure and strength QTL 71)
Bss72  (Bone structure and strength QTL 72)
Bss73  (Bone structure and strength QTL 73)
Bss74  (Bone structure and strength QTL 74)
Bss75  (Bone structure and strength QTL 75)
Bss76  (Bone structure and strength QTL 76)
Bss77  (Bone structure and strength QTL 77)
Bss78  (Bone structure and strength QTL 78)
Bss79  (Bone structure and strength QTL 79)
Bss80  (Bone structure and strength QTL 80)
Bss81  (Bone structure and strength QTL 81)
Bss82  (Bone structure and strength QTL 82)
Bss83  (Bone structure and strength QTL 83)
Bss84  (Bone structure and strength QTL 84)
Bss85  (Bone structure and strength QTL 85)
Bw96  (Body weight QTL 96)

Strains
F344/DuCrlSwe  (NA)
GK/KyoSwe  (Goto Kakizaki)


Additional Information