RGD Reference Report - Genes on rat chromosomes 3, 5, 10, and 16 are linked with facets of metabolic syndrome. - Rat Genome Database

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Genes on rat chromosomes 3, 5, 10, and 16 are linked with facets of metabolic syndrome.

Authors: Baguhl, R  Wilke, B  Kloting, N  Kloting, I 
Citation: Baguhl R, etal., Obesity (Silver Spring). 2009 Jun;17(6):1215-9. Epub 2009 Feb 19.
RGD ID: 2312642
Pubmed: PMID:19584880   (View Abstract at PubMed)
DOI: DOI:10.1038/oby.2008.658   (Journal Full-text)

WOKW (Wistar Ottawa Karlsburg W) rats develop metabolic syndrome closely resembling human disorder. In crossing studies between disease-prone WOKW and disease-resistant DA (Dark Agouti) rats, several quantitative trait loci (QTLs) were mapped. To prove the in vivo relevance of QTLs, congenic DA.WOKW rats, briefly termed DA.3aW, DA.3bW, DA.5W, DA.10W, and DA.16W, were generated by transferring chromosomal regions of WOKW chromosomes 3, 5, 10, and 16 onto DA genetic background. Male (n=12) and female (n=12) rats of each congenic strain and their parental strain DA were characterized for adiposity index (AI), serum leptin, and serum insulin as well as serum cholesterol and serum triglycerides as single facets of metabolic syndrome at the age of 30 weeks. The data showed a significant higher AI for male and female DA.3aW and female DA.16W compared with DA. Serum leptin was significantly elevated in male and female DA.3aW, DA.10W, and DA.16W rats in comparison with DA. Rats of both sexes of DA.10W and female DA.16W showed significantly elevated serum insulin in comparison to DA. Female rats of all congenics had significantly higher serum cholesterol compared with DA, while males did not differ. Finally, triglycerides were only elevated in male DA.16W. The results demonstrate an involvement of WOKW chromosomes 3, 5, 10, and 16 in developing facets of the metabolic syndrome.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DA.WOKW-(D10Mgh2-D10Rat4)/KRatincreased cholesterol level  IAGP only in females and compared to DA/KRGD 
DA.WOKW-(D16Rat88-D16Wox7)/KRatincreased cholesterol level  IAGP only in females and compared to DA/KRGD 
DA.WOKW-(D3Mgh5-D3Rat1)/KRatincreased cholesterol level  IAGP only in females and compared to DA/KRGD 
DA.WOKW-(D3Mit10-D3Rat189)/KRatincreased cholesterol level  IAGP only in females and compared to DA/KRGD 
DA.WOKW-(D5Mgh6-D5Mit5)/KRatincreased cholesterol level  IAGP only in females and compared to DA/KRGD 
Scl62Ratincreased cholesterol level  IDA  RGD 
Scl63Ratincreased cholesterol level  IDA  RGD 
Scl64Ratincreased cholesterol level  IDA  RGD 
Scl65Ratincreased cholesterol level  IDA  RGD 
DA.WOKW-(D10Mgh2-D10Rat4)/KRatincreased circulating insulin level  IAGP compared to DA/KRGD 
DA.WOKW-(D16Rat88-D16Wox7)/KRatincreased circulating insulin level  IAGP only in females and compared to DA/KRGD 
Insul15Ratincreased circulating insulin level  IDA  RGD 
Insul16Ratincreased circulating insulin level  IDA  RGD 
DA.WOKW-(D10Mgh2-D10Rat4)/KRatincreased circulating leptin level  IAGP compared to DA/KRGD 
DA.WOKW-(D16Rat88-D16Wox7)/KRatincreased circulating leptin level  IAGP compared to DA/KRGD 
DA.WOKW-(D3Mgh5-D3Rat1)/KRatincreased circulating leptin level  IAGP compared to DA/KRGD 
Slep7Ratincreased circulating leptin level  IDA  RGD 
Slep8Ratincreased circulating leptin level  IDA  RGD 
Slep9Ratincreased circulating leptin level  IDA  RGD 
Stl23Ratincreased circulating triglyceride level  IDA  RGD 
Bw94Ratincreased total body fat amount  IDA  RGD 
Bw95Ratincreased total body fat amount  IDA  RGD 
DA.WOKW-(D16Rat88-D16Wox7)/KRatincreased total body fat amount  IAGP only in females and compared to DA/KRGD 
DA.WOKW-(D3Mgh5-D3Rat1)/KRatincreased total body fat amount  IAGP compared to DA/KRGD 
Objects Annotated

QTLs
Bw94  (Body weight QTL 94)
Bw95  (Body weight QTL 95)
Insul15  (Insulin level QTL 15)
Insul16  (Insulin level QTL 16)
Scl62  (Serum cholesterol level QTL 62)
Scl63  (Serum cholesterol level QTL 63)
Scl64  (Serum cholesterol level QTL 64)
Scl65  (Serum cholesterol level QTL 65)
Slep7  (Serum leptin concentration QTL 7)
Slep8  (Serum leptin concentration QTL 8)
Slep9  (Serum leptin concentration QTL 9)
Stl23  (Serum triglyceride level QTL 23)

Objects referenced in this article
QTL BW17_H Body weight QTL 17 (human) Homo sapiens
QTL Mbsyd_m metabolic syndrome (mouse) Mus musculus
QTL Mlepq1_m M16 leptin QTL 1 (mouse) Mus musculus
QTL Scl20 Serum cholesterol level QTL 20 Rattus norvegicus
Strain WOKW/K null Rattus norvegicus

Additional Information