RGD Reference Report - Antioxidant and hepatoprotective activities of Cirsium setidens Nakai against CCl4-induced liver damage. - Rat Genome Database

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Antioxidant and hepatoprotective activities of Cirsium setidens Nakai against CCl4-induced liver damage.

Authors: Lee, SH  Heo, SI  Li, L  Lee, MJ  Wang, MH 
Citation: Lee SH, etal., Am J Chin Med. 2008;36(1):107-14.
RGD ID: 2312624
Pubmed: PMID:18306454   (View Abstract at PubMed)
DOI: DOI:10.1142/S0192415X0800562X   (Journal Full-text)

The antioxidant activity and hepatoprotective potential of Cirsium setidens Nakai, a widely used medicinal plant, were investigated. The n-butanol (n-BuOH) fraction of leaves and roots of C. setidens had a higher 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity than the other soluble fractions. The n-BuOH fraction of roots of C. setidens had a significant hepatoprotective activity at a dose of 500 mg/kg compared to that of a standard agent. The biochemical results were confirmed by histological observations indicating that C. setidens extract decreased ballooning degeneration in response to CCl(4) treatment. The n-BuOH fraction reduced CCl(4)-induced liver injury in rats, and transcript levels of genes encoding antioxidant enzymes such as glutathione peroxidase 1 (GPO1), glutathione peroxidase 3 (GPO3) and superoxide dismutase (SOD1) were elevated in the livers of rats treated with this fraction (500 mg/kg). Based on these results, we suggest that the C. setidens extract has hepatoprotective effect related to its antioxidant activity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GPX1HumanCarbon Tetrachloride Poisoning  ISORGD:2729 RGD 
GPX3HumanCarbon Tetrachloride Poisoning treatmentISORGD:69224 RGD 
Gpx1RatCarbon Tetrachloride Poisoning  IEP  RGD 
Gpx1MouseCarbon Tetrachloride Poisoning  ISORGD:2729 RGD 
Gpx3RatCarbon Tetrachloride Poisoning treatmentIEP  RGD 
Gpx3MouseCarbon Tetrachloride Poisoning treatmentISORGD:69224 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gpx1  (glutathione peroxidase 1)
Gpx3  (glutathione peroxidase 3)

Genes (Mus musculus)
Gpx1  (glutathione peroxidase 1)
Gpx3  (glutathione peroxidase 3)

Genes (Homo sapiens)
GPX1  (glutathione peroxidase 1)
GPX3  (glutathione peroxidase 3)


Additional Information