RGD Reference Report - Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Fromter rat. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Fromter rat.

Authors: Schulz, A  Hansch, J  Kuhn, K  Schlesener, M  Kossmehl, P  Nyengaard, JR  Wendt, N  Huber, M  Kreutz, R 
Citation: Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22.
RGD ID: 2312602
Pubmed: PMID:18647879   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.90270.2008   (Journal Full-text)

The Munich Wistar Fromter (MWF) rat represents a genetic model with an inherited nephron deficit and exhibits mild hypertension and progressive albuminuria, which is more pronounced in males than females. Previously, we demonstrated in a consomic strain that replacement of a quantitative trait locus on chromosome 6 normalized the nephron deficit and suppressed albuminuria development, suggesting a link between the two findings. Here we tested the role of a second major locus linked to albuminuria in MWF on chromosome 8 and generated the consomic strain MWF-8(SHR) by transfer of chromosome 8 from spontaneously hypertensive rats (SHR) into MWF. The early onset of albuminuria at 8 wk of age in MWF (>50-fold increase compared with SHR) was significantly suppressed in consomic animals, and the development of marked proteinuria at 32 wk significantly diminished. Total nephron number in consomic rats (23,771 +/- 1,352) and MWF (27,028 +/- 1,322) were similar and significantly lower (-36%) compared with SHR (36,979 +/- 1,352, P < 0.0001). The development of mild albuminuria in female MWF was also significantly diminished in MWF-8(SHR). Thus, the development of overt and mild albuminuria in male and female MWF rats is not a mandatory consequence of the inherited nephron deficit. The locus on chromosome 8 appears of interest, because its exchange between MWF and SHR protects against the development of albuminuria in MWF-8(SHR) animals despite their inherited nephron deficit and higher systolic blood pressure.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MWF/FubRkbRatAlbuminuria  IAGP as compared to SHR/FubRkb and MWF-Chr 8SHR/RkbRGD 
MWF-Chr 8SHR/RkbRatglomerulosclerosis  IAGP as compared to SHR/FubRkbRGD 
MWF/FubRkbRatglomerulosclerosis  IAGP as compared to SHR/FubRkbRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MWF-Chr 8SHR/RkbRatdecreased heart left ventricle weight  IAGP as compared to SHR/FubRkbRGD 
MWF/FubRkbRatdecreased heart left ventricle weight  IAGP as compared to SHR/FubRkbRGD 
MWF-Chr 8SHR/RkbRatdecreased kidney weight  IAGP as compared to SHR/FubRkbRGD 
MWF/FubRkbRatdecreased kidney weight  IAGP compared to SHR/FubRkb strainRGD 
MWF-Chr 8SHR/RkbRatdecreased systemic arterial systolic blood pressure  IAGP as compared to SHR/FubRkbRGD 
MWF/FubRkbRatdecreased systemic arterial systolic blood pressure  IAGP compared to SHR/FubRkb strainRGD 
MWF-Chr 8SHR/RkbRatincreased blood urea nitrogen level  IAGP as compared to SHR/FubRkbRGD 
MWF/FubRkbRatincreased blood urea nitrogen level  IAGP as compared to SHR/FubRkbRGD 
MWF-Chr 8SHR/RkbRatincreased circulating creatine level  IAGP as compared to SHR/FubRkbRGD 
MWF/FubRkbRatincreased circulating creatine level  IAGP as compared to SHR/FubRkbRGD 
MWF-Chr 8SHR/RkbRatincreased creatinine clearance  IAGP as compared to MWF/FubRkbRGD 
MWF-Chr 8SHR/RkbRatincreased urine protein level  IAGP as compared to SHR/FubRkbRGD 
MWF-Chr 8SHR/RkbRatrenal interstitial fibrosis  IAGP as compared to SHR/FubRkbRGD 
MWF/FubRkbRatrenal interstitial fibrosis  IAGP as compared to SHR/FubRkbRGD 

Objects Annotated

Strains
MWF-Chr 8SHR/Rkb  (NA)
MWF/FubRkb  (Munich Wistar Fromter)


Additional Information