RGD Reference Report - Genetic mapping found major QTLs for antibody-induced glomerulonephritis in WKY rats. - Rat Genome Database

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Genetic mapping found major QTLs for antibody-induced glomerulonephritis in WKY rats.

Authors: Kose, H  Sado, Y  Yamada, T  Matsumoto, K 
Citation: Kose H, etal., Exp Anim. 2009 Apr;58(2):193-8.
RGD ID: 2312387
Pubmed: PMID:19448344   (View Abstract at PubMed)

Genetic bases of glomerulonephritis, a major cause of kidney dysfunction in humans and one of the most characteristic complications of autoimmune disorders such as Goodpasture syndrome, are complex. The Wistar-Kyoto (WKY) rat strain is well characterized for its susceptibility to autoantibodies against glomerular basement membrane (GBM), however the molecular mechanisms underlining the phenotype are largely unknown. Here we performed a whole genome scan using a backcross (BC) F(1) (WKY x DA) x WKY population, for which the DA rat is a nonsusceptible control strain. We found two significant QTLs on chromosomes 1 and 12, which were involved in elevated levels of proteinuria and kidney weight index, respectively. The relevance of these QTLs with the genetic factors involved in autoimmunity and renal disease is discussed.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kidm41Ratanti-basement membrane glomerulonephritis  IAGP anti-GBM monoclonal antibody and b35RGD 
Pur17Ratanti-basement membrane glomerulonephritis  IAGP anti-GBM monoclonal antibody and b35RGD 
Pur17Ratproteinuria  IAGP anti-GBM monoclonal antibody and b35RGD 
WKY/NCrlRatproteinuria MODEL: inducedIAGP induced by anti-GBM monoclonal antibody and compared to DA/SlcRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kidm41Ratdecreased kidney weight  IDA  RGD 
Pur17Ratincreased urine protein level  IDA  RGD 

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Objects Annotated

QTLs
Kidm41  (Kidney mass QTL 41)
Pur17  (Proteinuria QTL 17)

Strains
DA/Slc  (dark agouti)
WKY/NCrl  (NA)


Additional Information