RGD Reference Report - Different inflammatory responses are associated with Ureaplasma parvum-induced UTI and urolith formation. - Rat Genome Database

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Different inflammatory responses are associated with Ureaplasma parvum-induced UTI and urolith formation.

Authors: Reyes, L  Reinhard, M  Brown, MB 
Citation: Reyes L, etal., BMC Infect Dis. 2009 Jan 26;9:9.
RGD ID: 2311084
Pubmed: PMID:19171043   (View Abstract at PubMed)
PMCID: PMC2656517   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-2334-9-9   (Journal Full-text)

BACKGROUND: Epidemiologic studies show a strong association between Ureaplasmas and urogenital tract disease in humans. Since healthy humans can be colonized with Ureaplasmas, its role as a pathogen remains controversial. In order to begin to define the role of the host in disease, we developed a rodent model of urinary tract infection (UTI) using Fischer 344 (F344) rats. Animals were inoculated with sterile broth, 10(1), 10(3), 10(5), 10(7), or 10(9) log CFU of a rat-adapted strain of Ureaplasma parvum. RESULTS: Infected animals exhibited two distinct profiles, asymptomatic UTI and UTI complicated with struvite urolithiasis. Inoculum dose of U. parvum affected the incidence of UTI, and 50% to 57% of animals inoculated with >or= 10(7) CFU of U. parvum remained infected (p < 0.04). However, inoculum dose did not influence immune response to U. parvum. Asymptomatic UTI was characterized by a minimal immune response that was predominantly monocytic and lymphocytic, with limited lesions, and elevated urinary levels of IFN-gamma, IL-18 and MCP-1 (P



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL18Humanurinary tract infection  ISOIl18 (Rattus norvegicus)protein:increased expression:urineRGD 
IL1AHumanurinary tract infection  ISOIl1a (Rattus norvegicus)protein:increased expression:urineRGD 
IL1BHumanurinary tract infection  ISOIl1b (Rattus norvegicus)protein:increased expression:urineRGD 
Il18Raturinary tract infection  IEP protein:increased expression:urineRGD 
Il18Mouseurinary tract infection  ISOIl18 (Rattus norvegicus)protein:increased expression:urineRGD 
Il1aRaturinary tract infection  IEP protein:increased expression:urineRGD 
Il1aMouseurinary tract infection  ISOIl1a (Rattus norvegicus)protein:increased expression:urineRGD 
Il1bRaturinary tract infection  IEP protein:increased expression:urineRGD 
Il1bMouseurinary tract infection  ISOIl1b (Rattus norvegicus)protein:increased expression:urineRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)
Il1a  (interleukin 1 alpha)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il18  (interleukin 18)
Il1a  (interleukin 1 alpha)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL18  (interleukin 18)
IL1A  (interleukin 1 alpha)
IL1B  (interleukin 1 beta)


Additional Information