RGD Reference Report - Insights on eukaryotic translation initiation factor 5A (eIF5A) in the brain and aging. - Rat Genome Database

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Insights on eukaryotic translation initiation factor 5A (eIF5A) in the brain and aging.

Authors: Luchessi, AD  Cambiaghi, TD  Alves, AS  Parreiras-E-Silva, LT  Britto, LR  Costa-Neto, CM  Curi, R 
Citation: Luchessi AD, etal., Brain Res. 2008 Sep 4;1228:6-13. Epub 2008 Jun 24.
RGD ID: 2308860
Pubmed: PMID:18606156   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainres.2008.06.057   (Journal Full-text)

Long-term memory, a persistent form of synaptic plasticity, requires translation of a subset of mRNA present in neuronal dendrites during a short and critical period through a mechanism not yet fully elucidated. Western blotting analysis revealed a high content of eukaryotic translation initiation factor 5A (eIF5A) in the brain of neonatal rats, a period of intense neurogenesis rate, differentiation and synaptic establishment, when compared to adult rats. Immunohistochemistry analysis revealed that eIF5A is present in the whole brain of adult rats showing a variable content among the cells from different areas (e.g. cortex, hippocampus and cerebellum). A high content of eIF5A in the soma and dendrites of Purkinje cells, key neurons in the control of motor long-term memory in the cerebellum, was observed. Detection of high eIF5A content was revealed in dendritic varicosities of Purkinje cells. Evidence is presented herein that a reduction of eIF5A content is associated to brain aging.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Eif5aRatdendrite  IDA  RGD 
Eif5aRatneuronal cell body  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Eif5a  (eukaryotic translation initiation factor 5A)


Additional Information