RGD Reference Report - ANGIOTENSIN CONVERTING ENZYME INHIBITORS IMPROVE HEPATIC STEATOSIS BY MODULATING EXPRESSION OF TUMOR NECROSIS FACTOR-Alpha, INTERLEUKIN-6 AND ADIPONECTIN RECEPTOR-2 IN RATS WITH TYPE 2 DIABETES.

Advanced Search (OLGA)

General

ANGIOTENSIN CONVERTING ENZYME INHIBITORS IMPROVE HEPATIC STEATOSIS BY MODULATING EXPRESSION OF TUMOR NECROSIS FACTOR-Alpha, INTERLEUKIN-6 AND ADIPONECTIN RECEPTOR-2 IN RATS WITH TYPE 2 DIABETES.
Authors:	Zhang, X Li, Z Liu, D Xu, X Mei, Z Shen, W
Citation:	Zhang X, etal., Clin Exp Pharmacol Physiol. 2008 Nov 28.
RGD ID:	2307264
Pubmed:	PMID:19076162 (View Abstract at PubMed)
DOI:	DOI:10.1111/j.1440-1681.2008.05129.x (Journal Full-text)
1. Angiotensin converting enzyme inhibitors (ACEIs) are hypotensive drugs. ACEIs prevent type 2 diabetes (T2D) in high risk individuals. However, in T2D, the effects of ACEIs on hepatic steatosis are unknown. We aimed to examine the effects of ACEIs on changes in liver histology and hepatic mRNA expression of adipokines in rats with T2D. 2. Thirty-six rats were divided into a normal control group, a T2D group and a fosinopril treatment group. After six weeks of treatment with fosinopril, an ACEI, we evaluated changes in liver histology, serum fasting glucose (FG), insulin (INS), triglyceride (TG), total cholersterol (TCHO), alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, adiponectin and hepatic TNF-alpha, IL-6 and adiponectin receptor-2 (adipoR2) mRNA. 3. The degree of hepatic steatosis and inflammation, serum FG, INS, TG, TCHO, ALT, TNF-alpha and IL-6 concentrations, and hepatic TNF-alpha and IL-6 mRNA expression in rats with T2D were significantly higher compared with normal controls. Serum adiponectin concentration and hepatic adipoR2 mRNA expression in rats with T2D were significantly lower compared with normal controls. Fosinopril significantly reduced the degree of hepatic steatosis, serum FG, INS, ALT, TNF-alpha and IL-6 concentrations, and hepatic TNF-alpha and IL-6 mRNA expression. Fosinopril significantly increased serum adiponectin concentration and hepatic adipoR2 mRNA expression. 4. ACEIs improved insulin sensitivity and hepatic steatosis in rats with T2D by increasing circulating adiponectin and hepatic adipoR2 level, in addition to reducing pro-inflammatory cytokines in the circulation and liver.

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
ADIPOR2	Human	steatotic liver disease	treatment	ISO	Adipor2 (Rattus norvegicus)	associated with Diabetes Mellitus and Experimental	RGD
Adipor2	Mouse	steatotic liver disease	treatment	ISO	Adipor2 (Rattus norvegicus)	associated with Diabetes Mellitus and Experimental	RGD
Adipor2	Rat	steatotic liver disease	treatment	IEP		associated with Diabetes Mellitus and Experimental	RGD
IL6	Human	steatotic liver disease		ISO	Il6 (Rattus norvegicus)	associated with Diabetes Mellitus more ...	RGD
Il6	Rat	steatotic liver disease		IAGP		associated with Diabetes Mellitus more ...	RGD
Il6	Mouse	steatotic liver disease		ISO	Il6 (Rattus norvegicus)	associated with Diabetes Mellitus more ...	RGD

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
ADIPOR2	Human	fosinopril	increases expression	ISO	Adipor2 (Rattus norvegicus)	fosinopril increases expression of adipor2 mRNA in rat liver	RGD
Adipor2	Rat	fosinopril	increases expression	EXP		fosinopril increases expression of adipor2 mRNA in rat liver	RGD
Adipor2	Mouse	fosinopril	increases expression	ISO	Adipor2 (Rattus norvegicus)	fosinopril increases expression of adipor2 mRNA in rat liver	RGD

Objects Annotated

Genes (Rattus norvegicus)

Adipor2 (adiponectin receptor 2)

Il6 (interleukin 6)

Genes (Mus musculus)

Adipor2 (adiponectin receptor 2)

Il6 (interleukin 6)

Genes (Homo sapiens)

ADIPOR2 (adiponectin receptor 2)

IL6 (interleukin 6)

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Create Name:

Description:

Send us a Message

ANGIOTENSIN CONVERTING ENZYME INHIBITORS IMPROVE HEPATIC STEATOSIS BY MODULATING EXPRESSION OF TUMOR NECROSIS FACTOR-Alpha, INTERLEUKIN-6 AND ADIPONECTIN RECEPTOR-2 IN RATS WITH TYPE 2 DIABETES.