RGD Reference Report - MHC and non-MHC gene regulation of disease susceptibility and disease course in experimental inflammatory peripheral neuropathy. - Rat Genome Database

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MHC and non-MHC gene regulation of disease susceptibility and disease course in experimental inflammatory peripheral neuropathy.

Authors: De Graaf, KL  Wallstrom, E  Muhallab, S  Wiesmuller, KH  Olsson, T  Weissert, R 
Citation: de Graaf KL, etal., J Neuroimmunol. 2004 Oct;155(1-2):73-84.
RGD ID: 2306736
Pubmed: PMID:15342198   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2004.06.001   (Journal Full-text)

With a panel of rat strains, we demonstrate a strong impact of the MHC genotype on susceptibility and disease course in experimental autoimmune neuritis induced with peripheral nerve myelin or the P2 peptide 58-81 (KNTEISFKLGQEFEETTADNRKTK). Beside the MHC genotype, non-MHC genes determined disease susceptibility and resistance. The type of disease induced with P2 58-81 was strongly correlated to the strength of the MHC class II isotype interaction with P2 58-81. These findings suggest a link between susceptibility and acute versus chronic disease courses on one hand and the strength of the MHC class II molecule/peptide affinity on the other hand.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table  |  Show All Strains Clinical Measurement

Strains with Phenominer Data Strains with phenominer data
ACI/SegHsd F344/NHsd COP
DA/ZtmKini PVG.1AV1 PVG
LEW.1WR1/WorBrm LEW.1AR1/Ztm LEW.1F
LEW.1N LEW.1AV1/Kini BN/OlaHsd
WF/NHsd LEW/Han

Objects Annotated

QTLs
Ean1  (Experimental allergic neuritis QTL 1)

Strains
DA/Ztm  (NA)
LEW.1AR1/Ztm  (NA)
LEW.1AV1  (NA)
LEW.1F  (NA)
LEW.1N  (NA)
LEW.1WR1/WorBrm  (NA)
LEW/Ztm  (LEW/Ztm)
PVG.1AV1  (Piebald-Virol-Glaxo)


Additional Information