RGD Reference Report - Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. - Rat Genome Database

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Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes.

Authors: Huang, Y  Myers, SJ  Dingledine, R 
Citation: Huang Y, etal., Nat Neurosci. 1999 Oct;2(10):867-72.
RGD ID: 2306469
Pubmed: PMID:10491605   (View Abstract at PubMed)
DOI: DOI:10.1038/13165   (Journal Full-text)

Many genes whose expression is restricted to neurons in the brain contain a silencer element (RE1/NRSE) that limits transcription in nonneuronal cells by binding the transcription factor REST (also named NRSF or XBR). Although two independent domains of REST are known to confer repression, the mechanisms of transcriptional repression by REST remain obscure. We provide multiple lines of evidence that the N-terminal domain of REST represses transcription of the GluR2 and type II sodium-channel genes by recruiting the corepressor Sin3A and histone deacetylase (HDAC) to the promoter region in nonneuronal cells. These results identify a general mechanism for controlling the neuronal expression pattern of a specific set of genes via the RE1 silencer element.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Hdac1Ratprotein-containing complex  IDA  RGD 
RestRatprotein-containing complex  IDA  RGD 
Sin3aRatprotein-containing complex  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RestRatprotein-containing complex binding  IDA  RGD 
Sin3aRatprotein-containing complex binding  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hdac1  (histone deacetylase 1)
Rest  (RE1-silencing transcription factor)
Sin3a  (SIN3 transcription regulator family member A)


Additional Information