RGD Reference Report - Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system. - Rat Genome Database

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Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system.

Authors: Nishiguchi, M  Kinoshita, H  Mostofa, J  Taniguchi, T  Ouchi, H  Minami, T  Hatake, K  Utsumi, T  Motomura, H  Hishida, S 
Citation: Nishiguchi M, etal., Alcohol Alcohol. 2002 Jan-Feb;37(1):9-12.
RGD ID: 2306323
Pubmed: PMID:11825850   (View Abstract at PubMed)

A significant difference in blood-acetaldehyde concentration was observed between high alcohol-preference (HAP) rats and low alcohol-preference (LAP) rats, newly developed different alcohol preference lines. This difference of acetaldehyde accumulation may be due to cytosolic aldehyde dehydrogenase (ALDH1) polymorphism, which has been reported previously. As the doses of ethanol we employed are higher than that of voluntary drinking, there may be little direct relationship between acetaldehyde accumulation and alcohol preference. We suggest therefore that the ALDH1 polymorphism is associated with alcohol preference in HAP/LAP lines through some other unidentified mechanism.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Aldh1a1Ratalcohol preference  IAGP DNA:polymorphismRGD 
Objects Annotated

Genes (Rattus norvegicus)
Aldh1a1  (aldehyde dehydrogenase 1 family, member A1)


Additional Information