RGD Reference Report - The H19 locus acts in vivo as a tumor suppressor. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

The H19 locus acts in vivo as a tumor suppressor.

Authors: Yoshimizu, T  Miroglio, A  Ripoche, MA  Gabory, A  Vernucci, M  Riccio, A  Colnot, S  Godard, C  Terris, B  Jammes, H  Dandolo, L 
Citation: Yoshimizu T, etal., Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12417-22. Epub 2008 Aug 21.
RGD ID: 2306169
Pubmed: PMID:18719115   (View Abstract at PubMed)
PMCID: PMC2527926   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.0801540105   (Journal Full-text)

The H19 locus belongs to a cluster of imprinted genes that is linked to the human Beckwith-Wiedemann syndrome. The expression of H19 and its closely associated IGF2 gene is frequently deregulated in some human tumors, such as Wilms' tumors. In these cases, biallelic IGF2 expression and lack of expression of H19 are associated with hypermethylation of the imprinting center of this locus. These observations and others have suggested a potential tumor suppressor effect of the H19 locus. Some studies have also suggested that H19 is an oncogene, based on tissue culture systems. We show, using in vivo murine models of tumorigenesis, that the H19 locus controls the size of experimental teratocarcinomas, the number of polyps in the Apc murine model of colorectal cancer and the timing of appearance of SV40-induced hepatocarcinomas. The H19 locus thus clearly displays a tumor suppressor effect in mice.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
H19Ratteratocarcinoma  ISOH19 (Mus musculus) RGD 
H19Mouseteratocarcinoma  IAGP  RGD 
H19Humanteratocarcinoma  ISOH19 (Mus musculus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
H19  (H19 imprinted maternally expressed transcript)

Genes (Mus musculus)
H19  (H19, imprinted maternally expressed transcript)

Genes (Homo sapiens)
H19  (H19 imprinted maternally expressed transcript)


Additional Information