RGD Reference Report - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban - Rat Genome Database

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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban

Authors: Zhang, Z  Si, YC  Bai, LM 
Citation: Zhang Z, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Oct;27(10):916-8.
RGD ID: 2303186
Pubmed: PMID:17990461   (View Abstract at PubMed)

OBJECTIVE: To explore the acting mechanism of Banxia Xiexin Decoction (BXD) and its disassembled recipes on stress gastric ulcer, for providing references to the scientific researches on the assembling rule of BXD. METHODS: The rat model of acute gastric ulcer was established by water immersion-restraint stress. The experimental rats were divided into the normal group, the model group and the treated groups treated with BXD and its disassembled recipes respectively to observe the therapeutic efficacy and the changes of somatostatin (SS) expression in brain and gastric tissues. RESULTS: In the model group, the SS expression was 0.0237 +/- 0.0056 in brain and 0.0171 +/- 0.0053 in gastric tissue respectively, which was significantly lower than those in the normal group (0.0305 +/- 0.0024 and 0.0282 +/- 0.0037) respectively. Compared to the model group, the two indexes in rats treated with full BXD were 0.0294 +/- 0.0050 and 0.0288 +/- 0.0027, treated with sweet flavor portion were 0.0314 +/- 0.0027 and 0.0219 +/- 0.0059, all showed increase of SS expression, and the increment was more significant in the former. CONCLUSION: BXD can increase the expression of SS to realize its therapeutic efficacy, and the recipe was assembled rationally.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SSTHumangastric ulcer  ISOSst (Rattus norvegicus) RGD 
SstRatgastric ulcer  IEP  RGD 
SstMousegastric ulcer  ISOSst (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sst  (somatostatin)

Genes (Mus musculus)
Sst  (somatostatin)

Genes (Homo sapiens)
SST  (somatostatin)


Additional Information