RGD Reference Report - Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

Authors: Li, DQ  Cai, W  Li, XJ  Niu, DD  Duan, JF 
Citation: Li DQ, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008 Sep;37(5):468-71.
RGD ID: 2303174
Pubmed: PMID:18925713   (View Abstract at PubMed)

OBJECTIVE: To investigate the changes of encephalic contents of somatostatin (SS) and arginine vasopressin (AVP) in rats with vascular dementia. METHODS: Twenty-four male Sprague-Dawley rats were randomly divided into three groups: vascular dementia group (VDMG), sham operation group (SOG) and control group (CG). The vascular dementia model was established by permanent bilateral vertebral artery occlusion through electric coagulation and shut-off the bilateral carotid arteries. The remember behavior of animals was tested and the contents of SS and AVP in various encephalic region (frontal cortex, temporal lobe, hippocampus, cerebral ganglion and corpora striatum) were determined with radioimmunoassay. RESULT: During the 15-day-long remembering test, the frequency of making mistakes in the VDMG was higher remarkably than that in SOG and CG (P<0.05); and the relative contents of SS were decreased in frontal area cortex, temporal lobe, hippocampus, cerebral ganglion and corpora striatum (P<0.01), while decrease of AVP contents was only detected in temporal lobe and corpora striatum (P<0.05). CONCLUSION: The disturbance of learning and memory function might be associated with SS and AVP after multiple cerebral infarction in the animals.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AVPHumanvascular dementia  ISOAvp (Rattus norvegicus)protein:decreased expression:brainRGD 
AvpRatvascular dementia  IEP protein:decreased expression:brainRGD 
AvpMousevascular dementia  ISOAvp (Rattus norvegicus)protein:decreased expression:brainRGD 
SSTHumanvascular dementia  ISOSst (Rattus norvegicus)protein:decreased expression:brainRGD 
SstRatvascular dementia  IEP protein:decreased expression:brainRGD 
SstMousevascular dementia  ISOSst (Rattus norvegicus)protein:decreased expression:brainRGD 

Objects Annotated

Genes (Rattus norvegicus)
Avp  (arginine vasopressin)
Sst  (somatostatin)

Genes (Mus musculus)
Avp  (arginine vasopressin)
Sst  (somatostatin)

Genes (Homo sapiens)
AVP  (arginine vasopressin)
SST  (somatostatin)


Additional Information