RGD Reference Report - Analysis and comparison of new candidate loci for hypertension between genetic hypertensive rat strains. - Rat Genome Database

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Analysis and comparison of new candidate loci for hypertension between genetic hypertensive rat strains.

Authors: Takami, S  Higaki, J  Miki, T  Katsuya, T  Nakata, Y  Rakugi, H  Serikawa, T  Ogihara, T 
Citation: Takami S, etal., Hypertens Res. 1996 Mar;19(1):51-6.
RGD ID: 2303163
Pubmed: PMID:8829824   (View Abstract at PubMed)

To search for the genes that determine the level of blood pressure, we performed linkage analyses using rat microsatellite markers in two sets of F2 rats derived from two hypertensive rat strains and one normotensive rat strain. In the first F2 progeny obtained from spontaneously hypertensive rats and Wistar-Kyoto rats, it was found that two different loci cosegregated with blood pressure. One was gamma-crystallin locus on rat chromosome 9, which has a hypertensive effect, and the other was peroxisomal 3-keto acyl-CoA thiolase locus on rat chromosome 8, which has a hypotensive effect. Then, we studied the same loci in second F2 progeny obtained from Dahl/Iwai salt-sensitive rats and Wistar-Kyoto rats. It was found that the locus located on rat chromosome 8 also had a hypotensive effect, although the others were not cosegregated with blood pressure in this cross. We suggest that a new locus for hypertension is located on rat chromosome 9 and that a locus on rat chromosome 8 has a common effect that makes blood pressure decrease in different hypertensive strains.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp332Rathypertension  IAGP  RGD 
Bp330RatHypotension  IAGP  RGD 
Bp331RatHypotension  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp330Ratdecreased systemic arterial systolic blood pressure  IDA  RGD 
Bp331Ratdecreased systemic arterial systolic blood pressure  IDA  RGD 
Bp332Ratincreased systemic arterial systolic blood pressure  IDA  RGD 
Objects Annotated

QTLs
Bp330  (Blood pressure QTL 330)
Bp331  (Blood pressure QTL 331)
Bp332  (Blood pressure QTL 332)

Strains
SHR/Kyo  (spontaneous hypertension rat)
WKY/NCrlCrlj  (NA)

Objects referenced in this article
QTL Bp300 Blood pressure QTL 300 Rattus norvegicus
QTL Bp301 Blood pressure QTL 301 Rattus norvegicus
QTL Bp302 Blood pressure QTL 302 Rattus norvegicus

Additional Information