RGD Reference Report - The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis. - Rat Genome Database

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The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis.

Authors: Wernhoff, P  Olofsson, P  Holmdahl, R 
Citation: Wernhoff P, etal., Arthritis Rheum. 2003 Dec;48(12):3584-96.
RGD ID: 2302026
Pubmed: PMID:14674011   (View Abstract at PubMed)
DOI: DOI:10.1002/art.11342   (Journal Full-text)

OBJECTIVE: To investigate the genetic regulation of rheumatoid factor (RF) in a rat model of rheumatoid arthritis, in order to gain understanding of the enigmatic role of RF in the disease. METHODS: IgM-RF and IgG-RF, as well as total levels of immunoglobulins of different subclasses, were measured in sera from rats with pristane-induced arthritis (PIA). The major gene regions were identified by linkage analysis of genetically segregating crosses. RESULTS: The production of RF was found to correlate with development of arthritis and to be higher in females than in males. Surprisingly, the relatively arthritis-resistant E3 strain had higher levels of RF than the arthritis-susceptible DA strain. In an (E3 x DA)F(2) cohort a major locus controlling the levels of IgM-RF in serum was identified on chromosome 11 (Rf1) and another on chromosome 16 (Rf3), and these were not related to arthritis susceptibility. However, the Rf2 locus on chromosome 4 controlled IgG-RF levels, IgG2a levels, and chronic arthritis in males (Pia5). Some previously defined arthritis loci (Pia4, Pia6, Pia7, and Pia8) were found to also control immunoglobulin levels in serum. CONCLUSION: RFs are produced in the rat PIA model and correlate with development of arthritis. Gene regions controlling RF and serum immunoglobulin levels were identified, of which some cosegregated with arthritis. This suggests a new focus of study to elucidate the role of RF in the pathogenesis of arthritis.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Pia27  (Pristane induced arthritis QTL 27)
Pia28  (Pristane induced arthritis QTL 28)
Pia29  (Pristane induced arthritis QTL 29)
Pia30  (Pristane induced arthritis QTL 30)
Pia31  (Pristane induced arthritis QTL 31)
Pia32  (Pristane induced arthritis QTL 32)
Pia33  (Pristane induced arthritis QTL 33)
Pia34  (Pristane induced arthritis QTL 34)
Pia35  (Pristane induced arthritis QTL 35)
Pia36  (Pristane induced arthritis QTL 36)
Pia37  (Pristane induced arthritis QTL 37)
Pia38  (Pristane induced arthritis QTL 38)
Pia39  (Pristane induced arthritis QTL 39)

Strains
DA/ZtmRhd  (NA)
E3/ZtmRhd  (NA)

Objects referenced in this article
QTL Apr1 Acute phase response QTL 1 Rattus norvegicus
QTL Cia12 Collagen induced arthritis QTL 12 Rattus norvegicus
QTL Cia2 Collagen induced arthritis QTL 2 Rattus norvegicus
QTL Eae7 Experimental allergic encephalomyelitis QTL 7 Rattus norvegicus
QTL Eae8 Experimental allergic encephalomyelitis QTL 8 Rattus norvegicus
QTL Pia4 Pristane induced arthritis QTL 4 Rattus norvegicus
QTL Pia6 Pristane induced arthritis QTL 6 Rattus norvegicus
QTL Pia7 Pristane induced arthritis QTL 7 Rattus norvegicus
QTL Pia8 Pristane induced arthritis QTL 8 Rattus norvegicus

Additional Information