RGD Reference Report - Interaction of AT1 receptors and V1a receptors-mediated effects in the central cardiovascular control during the post-infarct state. - Rat Genome Database

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Interaction of AT1 receptors and V1a receptors-mediated effects in the central cardiovascular control during the post-infarct state.

Authors: Cudnoch-Jedrzejewska, A  Dobruch, J  Puchalska, L  Szczepanska-Sadowska, E 
Citation: Cudnoch-Jedrzejewska A, etal., Regul Pept. 2007 Aug 16;142(3):86-94. Epub 2007 Feb 15.
RGD ID: 2300347
Pubmed: PMID:17350115   (View Abstract at PubMed)
DOI: DOI:10.1016/j.regpep.2007.01.010   (Journal Full-text)

Experimental objectives. Because myocardial infarct is associated with overactivation of brain angiotensin II (ANG II) and vasopressin (AVP) V1a receptors we decided to determine whether AT1 and V1a receptors-mediated effects of ANG II and AVP interact in central cardiovascular control during the post-infarct state. Four groups of infarcted and four groups of sham-operated conscious rats entered the study. Results. In the infarcted rats cerebroventricular infusion of AT1 (AT1ANT, losartan) and V1a antagonist {V1aANT,d(CH(2))(5)[Tyr(Me)(2)Ala-NH(2)(9)]VP} and combined infusion of both these compounds performed 4 weeks after induction of the infarct significantly and comparably reduced mean arterial blood pressure (MABP) in comparison to control experiments (artificial cerebrospinal fluid infusion). In the sham rats MABP was not affected by any of the infusions. In control experiments MABP and HR responses to an alarming air jet stress were significantly higher in the infarcted than in the sham rats. Both responses were normalized with the same effectiveness by administration of AT1ANT, V1aANT and AT1ANT+V1aANT. In the sham rats administration of these compounds did not affect MABP and HR responses to stress. Conclusion: The results provide evidence for interaction of AT1 and V1a receptors-mediated effects of ANG II and AVP in the central cardiovascular control during the post-infarct state.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Avpr1aRatpositive regulation of systemic arterial blood pressure  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Avpr1a  (arginine vasopressin receptor 1A)


Additional Information