RGD Reference Report - OLETF allele of hyperglycemic QTL Nidd3/of is dominant. - Rat Genome Database

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OLETF allele of hyperglycemic QTL Nidd3/of is dominant.

Authors: Kose, H  Yamada, T  Matsumoto, K 
Citation: Kose H, etal., Exp Anim. 2008 Apr;57(2):135-8.
RGD ID: 2300331
Pubmed: PMID:18421176   (View Abstract at PubMed)

The OLETF rat is a well-established model for the study of type 2 diabetes associated with obesity and has been shown to possess multiple hyperglycemic alleles in its genome. Here we focused on and carefully characterized one of the previously reported congenic strains, F.O-Nidd3/of that carries the OLETF allele of the Nidd3/of locus (also known as Niddm21 in the Rat Genome Database) in the normoglycemic F344 genetic background. A prominent finding was that the F1 progeny between the congenic and the F344 stain, whose genotype is heterozygote at the Nidd3/of locus, showed mild hyperglycemia equal to the parental congenic rat, suggesting that the OLETF allele is dominant. To our knowledge, this is the first study in which a diabetic QTL has been directly demonstrated to be dominant by using congenic strains.



Disease Annotations    
hyperglycemia  (IAGP)

Phenotype Annotations    

Mammalian Phenotype

Objects Annotated

QTLs
Niddm21  (Non-insulin dependent diabetes mellitus QTL 21)


Additional Information