RGD Reference Report - Linkage screen for BMD phenotypes in male and female COP and DA rat strains. - Rat Genome Database

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Linkage screen for BMD phenotypes in male and female COP and DA rat strains.

Authors: Koller, DL  Liu, L  Alam, I  Sun, Q  Econs, MJ  Foroud, T  Turner, CH 
Citation: Koller DL, etal., J Bone Miner Res. 2008 Sep;23(9):1382-8.
RGD ID: 2300109
Pubmed: PMID:18707222   (View Abstract at PubMed)
PMCID: PMC2683154   (View Article at PubMed Central)
DOI: DOI:10.1359/jbmr.080401   (Journal Full-text)

Because particular inbred strains of experimental animals are informative for only a subset of the genes underlying variability in BMD, we undertook a genome screen to identify quantitative trait loci (QTLs) in 828 F(2) progeny (405 males and 423 females) derived from the Copenhagen 2331 (COP) and dark agouti (DA) strains of rats. This screen was performed to complement our study in female Fischer 344 (F344) and Lewis (LEW) rats and to further delineate the factors underlying the complex genetic architecture of BMD in the rat model. Microsatellite genotyping was performed using markers at an average density of 20 cM. BMD was measured by pQCT and DXA. These data were analyzed in the R/qtl software to detect QTLs acting in both sexes as well as those having sex-specific effects. A QTL was detected in both sexes on chromosome 18 for midfemur volumetric BMD (vBMD; genome-wide, p < 0.01). On distal chromosome 1, a QTL was found for femur and vertebral aBMD as well as distal femur vBMD, and this QTL appears distinct from the proximal chromosome 1 QTL impacting BMD in our F344/LEW cross. Additional aBMD and vBMD QTLs and several sex-specific QTLs were also detected. These included a male-specific QTL (p < 0.01) on chromosome 8 and a female-specific QTL on chromosomes 7 and 14 (p < 0.01). Few of the QTLs identified showed overlap with the significant QTLs from the F344/LEW cross. These results confirm that the genetic influence on BMD in the rat model is quite complex and would seem to be influenced by a number of different genes, some of which have sex-specific effects.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bmd40Ratosteoporosis  IAGP  RGD 
Bmd41Ratosteoporosis  IAGP  RGD 
Bmd42Ratosteoporosis  IAGP  RGD 
Bmd43Ratosteoporosis  IAGP  RGD 
Bmd44Ratosteoporosis  IAGP  RGD 
Bmd45Ratosteoporosis  IAGP  RGD 
Bmd46Ratosteoporosis  IAGP  RGD 
Bmd47Ratosteoporosis  IAGP  RGD 
Bmd48Ratosteoporosis  IAGP  RGD 
Bmd49Ratosteoporosis  IAGP  RGD 
Bmd50Ratosteoporosis  IAGP  RGD 
Bmd51Ratosteoporosis  IAGP  RGD 
Bmd52Ratosteoporosis  IAGP  RGD 
Bmd53Ratosteoporosis  IAGP  RGD 
Bmd54Ratosteoporosis  IAGP  RGD 
Bmd55Ratosteoporosis  IAGP  RGD 
Bmd56Ratosteoporosis  IAGP  RGD 
Bmd57Ratosteoporosis  IAGP  RGD 
Bmd58Ratosteoporosis  IAGP  RGD 
Bmd59Ratosteoporosis  IAGP  RGD 
Bmd60Ratosteoporosis  IAGP  RGD 
Bmd61Ratosteoporosis  IAGP  RGD 
Bmd62Ratosteoporosis  IAGP  RGD 
Bmd63Ratosteoporosis  IAGP  RGD 
Bmd64Ratosteoporosis  IAGP  RGD 
Bmd65Ratosteoporosis  IAGP  RGD 
Bmd66Ratosteoporosis  IAGP  RGD 
Bmd67Ratosteoporosis  IAGP  RGD 
Bmd68Ratosteoporosis  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bmd40Ratabnormal bone mineral density  IDA  RGD 
Bmd41Ratabnormal bone mineral density  IDA  RGD 
Bmd42Ratabnormal bone mineral density  IDA  RGD 
Bmd43Ratabnormal bone mineral density  IDA  RGD 
Bmd44Ratabnormal bone mineral density  IDA  RGD 
Bmd45Ratabnormal bone mineral density  IDA  RGD 
Bmd46Ratabnormal bone mineral density  IDA  RGD 
Bmd47Ratabnormal bone mineral density  IDA  RGD 
Bmd48Ratabnormal bone mineral density  IDA  RGD 
Bmd49Ratabnormal bone mineral density  IDA  RGD 
Bmd50Ratabnormal bone mineral density  IDA  RGD 
Bmd51Ratabnormal bone mineral density  IDA  RGD 
Bmd52Ratabnormal bone mineral density  IDA  RGD 
Bmd53Ratabnormal bone mineral density  IDA  RGD 
Bmd54Ratabnormal bone mineral density  IDA  RGD 
Bmd55Ratabnormal bone mineral density  IDA  RGD 
Bmd56Ratabnormal bone mineral density  IDA  RGD 
Bmd57Ratabnormal bone mineral density  IDA  RGD 
Bmd58Ratabnormal bone mineral density  IDA  RGD 
Bmd59Ratabnormal bone mineral density  IDA  RGD 
Bmd60Ratabnormal bone mineral density  IDA  RGD 
Bmd61Ratabnormal bone mineral density  IDA  RGD 
Bmd62Ratabnormal bone mineral density  IDA  RGD 
Bmd63Ratabnormal bone mineral density  IDA  RGD 
Bmd64Ratabnormal bone mineral density  IDA  RGD 
Bmd65Ratabnormal bone mineral density  IDA  RGD 
Bmd66Ratabnormal bone mineral density  IDA  RGD 
Bmd67Ratabnormal bone mineral density  IDA  RGD 
Bmd68Ratabnormal bone mineral density  IDA  RGD 
Objects Annotated

Bmd40  (Bone mineral density QTL 40)
Bmd41  (Bone mineral density QTL 41)
Bmd42  (Bone mineral density QTL 42)
Bmd43  (Bone mineral density QTL 43)
Bmd44  (Bone mineral density QTL 44)
Bmd45  (Bone mineral density QTL 45)
Bmd46  (Bone mineral density QTL 46)
Bmd47  (Bone mineral density QTL 47)
Bmd48  (Bone mineral density QTL 48)
Bmd49  (Bone mineral density QTL 49)
Bmd50  (Bone mineral density QTL 50)
Bmd51  (Bone mineral density QTL 51)
Bmd52  (Bone mineral density QTL 52)
Bmd53  (Bone mineral density QTL 53)
Bmd54  (Bone mineral density QTL 54)
Bmd55  (Bone mineral density QTL 55)
Bmd56  (Bone mineral density QTL 56)
Bmd57  (Bone mineral density QTL 57)
Bmd58  (Bone mineral density QTL 58)
Bmd59  (Bone mineral density QTL 59)
Bmd60  (Bone mineral density QTL 60)
Bmd61  (Bone mineral density QTL 61)
Bmd62  (Bone mineral density QTL 62)
Bmd63  (Bone mineral density QTL 63)
Bmd64  (Bone mineral density QTL 64)
Bmd65  (Bone mineral density QTL 65)
Bmd66  (Bone mineral density QTL 66)
Bmd67  (Bone mineral density QTL 67)
Bmd68  (Bone mineral density QTL 68)

COP/OlaHsd  (NA)
DA/OlaHsd  (NA)

Additional Information