RGD Reference Report - Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats. - Rat Genome Database

RGD Reference Report - Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats. - Rat Genome Database

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General

Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats.
Authors:	Hiraoka-Yamamoto, J Nara, Y Yasui, N Onobayashi, Y Tsuchikura, S Ikeda, K
Citation:	Hiraoka-Yamamoto J, etal., Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):107-9.
RGD ID:	2300017
Pubmed:	PMID:14756693 (View Abstract at PubMed)
1. We established a new animal model of metabolic syndrome, SHRSP fatty (fa/fa) rats, by crossing stroke-prone spontaneously hypertensive rats of the Izumo strain (SHRSP/Izm) to Zucker fatty (ZF) (fa/fa) rats. 2. The SHRSP fatty (fa/fa) rats have a missense mutation of the leptin receptor gene and plasma leptin concentrations are augmented. The SHRSP fatty (fa/fa) rats develop obesity and hypertension simultaneously. 3. Plasma metabolic parameters, including glucose, insulin and total cholesterol and triglyceride levels, were markedly elevated in SHRSP fatty (fa/fa) rats compared with SHRSP/Izm rats. Plasma triglyceride concentrations in SHRSP fatty (fa/fa) rats were significantly elevated compared with those in ZF (fa/fa) rats. The weight of adipose tissues in SHRSP fatty (fa/fa) rats was greater than that of SHRSP/Izm rats. The phenotype of SHRSP fatty (fa/fa) rats is similar to that of human metabolic syndrome.

Annotation Click to see Annotation Detail View

Disease Annotations

Hypercholesterolemia (IAGP)

hyperinsulinism (IAGP)

hypertension (IAGP)

Metabolic Syndrome (IAGP)

obesity (IAGP)

Phenotype Annotations

Mammalian Phenotype

decreased systemic arterial systolic blood pressure (IAGP)

increased body weight (IAGP)

increased circulating cholesterol level (IAGP)

increased circulating glucose level (IAGP)

increased circulating insulin level (IAGP)

increased circulating leptin level (IAGP)

increased circulating triglyceride level (IAGP)

increased epididymal fat pad weight (IAGP)

increased liver weight (IAGP)

increased mesenteric fat pad weight (IAGP)

Objects Annotated

Strains

SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcr (NA)

Slc:ZUC-Lepr^fa-/- (Zucker fatty rats)

Additional Information