RGD Reference Report - HER-2/neu and p27Kip1 in progression of Fallopian tube carcinoma: an immunohistochemical and array comparative genomic hybridization study. - Rat Genome Database

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HER-2/neu and p27Kip1 in progression of Fallopian tube carcinoma: an immunohistochemical and array comparative genomic hybridization study.

Authors: Nowee, ME  Dorsman, JC  Piek, JM  Kosma, VM  Hamalainen, K  Verheijen, RH  Van Diest, PJ 
Citation: Nowee ME, etal., Histopathology. 2007 Nov;51(5):666-73.
RGD ID: 2299088
Pubmed: PMID:17927588   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2559.2007.02850.x   (Journal Full-text)

AIMS: To determine expression of p53, HER-2/neu and p27(Kip1) in serous Fallopian tube carcinoma (FTC) in relation to stage and grade, and to investigate DNA copy number changes of HER-2 and P27KIP1 as a potential mechanism of altered expression status. METHODS AND RESULTS: Immunohistochemistry was performed on 28 serous FTCs and 10 normal Fallopian tubes. p53 protein accumulated and p27(Kip1) was down-regulated significantly in early-stage FTCs compared with normal Fallopian tubes. HER-2/neu overexpression was absent in normal Fallopian tubes and in all stage I FTCs (n = 6) but present in 57% (12/21) of advanced-stage FTCs. No differences in expression between grade 2 and 3 tumours were detected. HER-2 gain/amplification was found by array comparative genomic hybridization in 23% (3/13) of analysed FTCs and all showed overexpression. HER-2/neu overexpression also occurred without DNA copy number changes in three other cases. For p27(Kip1), expression and DNA copy number were unrelated. CONCLUSIONS: p53 accumulation and p27(Kip1) down-regulation seem to be early events in Fallopian tube carcinogenesis. HER-2/neu showed overexpression, caused by gain/amplification in 50%, and may be involved in progression of FTC. These data contribute to a better understanding of the molecular carcinogenesis of FTC and to possible new therapeutic approaches.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CDKN1BHumanFallopian Tube Neoplasms  IEP protein:decreased expression:fallopian tubeRGD 
Cdkn1bRatFallopian Tube Neoplasms  ISOCDKN1B (Homo sapiens)protein:decreased expression:fallopian tubeRGD 
Cdkn1bMouseFallopian Tube Neoplasms  ISOCDKN1B (Homo sapiens)protein:decreased expression:fallopian tubeRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdkn1b  (cyclin-dependent kinase inhibitor 1B)

Genes (Mus musculus)
Cdkn1b  (cyclin dependent kinase inhibitor 1B)

Genes (Homo sapiens)
CDKN1B  (cyclin dependent kinase inhibitor 1B)


Additional Information