RGD Reference Report - Enhanced sympathetic control of renal function in rats congenic for the hypertension-related region on chromosome 1. - Rat Genome Database

RGD Reference Report - Enhanced sympathetic control of renal function in rats congenic for the hypertension-related region on chromosome 1. - Rat Genome Database

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Enhanced sympathetic control of renal function in rats congenic for the hypertension-related region on chromosome 1.
Authors:	Wang, T Kobayashi, Y Nabika, T Takabatake, T
Citation:	Wang T, etal., Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1055-60.
RGD ID:	2296063
Pubmed:	PMID:16445571 (View Abstract at PubMed)
DOI:	DOI:10.1111/j.1440-1681.2005.04304.x (Journal Full-text)
Recent studies suggest that a quantitative trait locus (QTL) for blood pressure (BP) on rat chromosome 1 is associated with exaggerated sympathetic nervous activity. The aim of the present study was to examine whether this QTL can affect BP by altering sympathetic control of renal function. Male stroke-prone spontaneously hypertensive rats of Izumo origin (SHRSP/Izm), Wistar-Kyoto rats (WKY/Izm) and rats from a WKY/Izm congenic strain that contains an SHRSP/Izm chromosomal segment between D1Wox29 and D1Arb21 (WKYpch1.0) were used. Clearance and micropuncture experiments were performed in anaesthetized rats after acute unilateral renal denervation (DN). Mean BP in sham-operated WKYpch1.0 was significantly higher than that in WKY/Izm. The DN procedure elicited a greater reduction in renal noradrenaline levels in SHRSP/Izm and WKYpch1.0 than in WKY/Izm. In both SHRSP/Izm and WKYpch1.0, DN decreased renal vascular resistance and filtration fraction, whereas it increased renal blood flow and urinary and fractional excretion of sodium. Unilateral renal denervation did not affect these parameters in WKY/Izm. Unilateral renal denervation decreased the tubuloglomerular feedback (TGF) responsiveness only in SHRSP/Izm, whereas it increased the non-perfused early proximal flow rate in SHRSP/Izm and WKYpch1.0. The results of the present study indicate that the renal sympathetic nervous system exerts enhanced tonic control of the renal vasculature and tubular function in SHRSP/Izm and WKYpch1.0, but not in WKY/Izm. Neural impact on the TGF response in WKYpch1.0 is indiscernible. Thus, a gene or genes in the QTL may influence BP, at least in part, through renal vasoconstriction and sodium retention mediated by the enhanced activity of the renal sympathetic nerves.

Annotation Click to see Annotation Detail View

Disease Annotations

hypertension (IAGP)

Phenotype Annotations

Mammalian Phenotype

abnormal renal sodium reabsorption (IAGP)

abnormal tubuloglomerular feedback response (IAGP)

decreased body weight (IAGP)

decreased kidney weight (IAGP)

decreased noradrenaline level (IAGP)

decreased renal plasma flow rate (IAGP)

decreased renal vascular resistance (IAGP)

decreased tubuloglomerular feedback response (IAGP)

increased hematocrit (IAGP)

increased mean systemic arterial blood pressure (IAGP)

increased renal plasma flow rate (IAGP)

increased renal vascular resistance (IAGP)

increased urine sodium level (IAGP)

polyuria (IAGP)

Objects Annotated

Strains

WKY.SHRSP-(D1Wox29-D1Arb21)/Izm (NA)

WKY/Izm (Wistar-Kyoto)

Objects referenced in this article

Strain	SHR/Izm	null	Rattus norvegicus

Additional Information