RGD Reference Report - Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice. - Rat Genome Database

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Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice.

Authors: Ockinger, J  Serrano-Fernandez, P  Moller, S  Ibrahim, SM  Olsson, T  Jagodic, M 
Citation: Ockinger J, etal., Genetics. 2006 Jul;173(3):1539-45. Epub 2006 Apr 19.
RGD ID: 2293859
Pubmed: PMID:16624898   (View Abstract at PubMed)
PMCID: PMC1526695   (View Article at PubMed Central)
DOI: DOI:10.1534/genetics.106.057406   (Journal Full-text)

Unbiased identification of susceptibility genes might provide new insights into pathogenic mechanisms that govern complex inflammatory diseases such as multiple sclerosis. In this study we fine mapped Eae18a, a region on rat chromosome 10 that regulates experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. We utilized two independent approaches: (1) in silico mapping based on sequence similarity between human multiple sclerosis susceptibility regions and rodent EAE quantitative trait loci and (2) linkage mapping in an F10 (DA x PVG.AV1) rat advanced intercrossed line. The linkage mapping defines Eae18a to a 5-Mb region, which overlaps one intergenomic consensus region identified in silico. The combined approach confirms experimentally, for the first time, the accuracy of the in silico method. Moreover, the shared intersection between the results of both mapping techniques defines a 1.06-Mb region containing 13 candidate genes for the regulation of neuroinflammation in humans, rats, and mice.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Encephalomyelitis  IAGP 2293859induced by MOGRGD 
Experimental Autoimmune Encephalomyelitis MODEL: inducedIAGP 2293859induced by MOGRGD 
multiple sclerosis  IAGP 2293859induced by MOGRGD 
multiple sclerosis MODEL: inducedIAGP 2293859induced by MOGRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
CNS inflammation  IDA 2293859induced by MOGRGD 
CNS inflammation inducedIAGP 2293859induced by MOGRGD 
weight loss  IDA 2293859induced by MOGRGD 
weight loss MODEL: inducedIAGP 2293859induced by MOGRGD 
Objects Annotated

Eae23  (Experimental allergic encephalomyelitis QTL 23)

Kini:DA,PVG-G10  (NA)

Objects referenced in this article
Strain DA/Ztm null Rattus norvegicus
QTL Eae18 Experimental allergic encephalomyelitis QTL 18 Rattus norvegicus
QTL Eae18a Experimental allergic encephalomyelitis QTL 18a Rattus norvegicus
QTL Eae3 Experimental allergic encephalomyelitis QTL 3 Rattus norvegicus
Strain PVG.1AV1 Piebald-Virol-Glaxo Rattus norvegicus

Additional Information