RGD Reference Report - Localization of genetic loci controlling hydronephrosis in the Brown Norway rat and its association with hematuria. - Rat Genome Database

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Localization of genetic loci controlling hydronephrosis in the Brown Norway rat and its association with hematuria.

Authors: Kota, LT  Schulz, H  Falak, S  Hubner, N  Osborne-Pellegrin, M 
Citation: Kota LT, etal., Physiol Genomics. 2008 Jun 3;.
RGD ID: 2293631
Pubmed: PMID:18523158   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00221.2007   (Journal Full-text)

The aim of this study was to investigate the genetic basis of congenital hydronephrosis (HN), a poorly defined pathological entity, using a rat model. The Brown Norway (BN) strain presents spontaneously a high incidence of apparently asymptomatic HN, whereas the LOU strain does not. A backcross was established between these two strains [BNx(BNxLOU)] and a genome-wide scan performed with 193 microsatellite markers on 121 males and 118 females of this population, which had been phenotyped and scored for HN severity (defined as the degree of renal pelvic dilation), followed by linkage analysis using Mapmaker/QTL software. Bilateral HN score was significantly linked to a locus on chromosome 6 (Z-scores 4.4 and 4.8 for all rats and for females respectively). Suggestive loci were identified on chromosomes 2 (for only right-sided HN) and 4. This is the first study in rat to identify genetic loci for HN. 3 candidate genes present in these loci were sequenced and insertions detected in Id2 and Agtr1b genes in BN, which did not however lead to modified expression as measured by quantitative PCR. Production of a congenic line for part of the chromosome 6 locus confirmed its involvement in HN, but the phenotype was mild. Evidence of hematuria was observed in 9.6% of the backcross rats, mostly males and only in kidneys with HN, but not necessarily in the most severely affected. Hematuria also occurs in the BN colony used here, where it is due to papilloma-like lesions involving pelvic epithelial proliferation, but not in the LOU. Key words: LOU rat, quantitative trait loci, congenic rats, renal pelvic epithelial proliferation.



Disease Annotations    
Hematuria  (IAGP)
hydronephrosis  (IAGP)

Phenotype Annotations    

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table  |  Show All Strains Clinical Measurement


Objects Annotated

QTLs
Kiddil1  (Kidney dilation QTL 1)
Kiddil2  (Kidney dilation QTL 2)
Kiddil3  (Kidney dilation QTL 3)
Kiddil4  (Kidney dilation QTL 4)
Kiddil5  (Kidney dilation QTL 5)
Kiddil6  (Kidney dilation QTL 6)
Kiddil7  (Kidney dilation QTL 7)
Kiddil8  (Kidney dilation QTL 8)
Kiddil9  (Kidney dilation QTL 9)


Additional Information