RGD Reference Report - Age-related hearing loss in the Fischer 344/NHsd rat substrain. - Rat Genome Database

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Age-related hearing loss in the Fischer 344/NHsd rat substrain.

Authors: Bielefeld, EC  Coling, D  Chen, GD  Li, M  Tanaka, C  Hu, BH  Henderson, D 
Citation: Bielefeld EC, etal., Hear Res. 2008 Apr 22;.
RGD ID: 2293526
Pubmed: PMID:18508213   (View Abstract at PubMed)
PMCID: PMC2556048   (View Article at PubMed Central)
DOI: DOI:10.1016/j.heares.2008.04.006   (Journal Full-text)

Studies of the F344 rat have shown a variety of age-related auditory anatomy and physiology changes. The current study was undertaken to clarify the ARHL in the F344 rat, by examining the auditory pathway of the F344/NHsd substrain that is distributed by Harlan Laboratories for research in the United States. The F344/NHsd rat begins to lose its hearing at about 12 months, and by 24 months, there are 50-60dB auditory brainstem response threshold shifts at 20 and 40kHz and 20dB losses at 5-10kHz. Distortion product otoacoustic emissions (DPOAE) amplitudes at 1.8-12kHz stimuli were depressed in the older (18-24 months) rats. Amplitude input-output functions of the compound action potential (CAP) were also depressed across frequency. The endocochlear potential (EP) was 90-100mV in the 3month old rats. All but one of the 24month old rats' EPs were in the +75-85mV range. Tympanometry revealed no differences in middle ear function between the young and older rats. Collectively, these findings suggest damage to the outer hair cells, but anatomical examination of the outer hair cells revealed a relative lack of cell loss compared to the magnitude of the hearing and DPOAE loss.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F344/NHsdRatHearing Loss onsetIAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F344/NHsdRatimpaired hearing onsetIAGP  RGD 
F344/NHsdRatincreased susceptibility to age-related hearing loss onsetIAGP  RGD 
Objects Annotated

Strains
F344/NHsd  (F344/NHsd)


Additional Information