RGD Reference Report - Wnt signalling and its impact on development and cancer. - Rat Genome Database

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Wnt signalling and its impact on development and cancer.

Authors: Klaus, A  Birchmeier, W 
Citation: Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
RGD ID: 2293188
Pubmed: PMID:18432252   (View Abstract at PubMed)
DOI: DOI:10.1038/nrc2389   (Journal Full-text)

The Wnt signalling pathway is an ancient system that has been highly conserved during evolution. It has a crucial role in the embryonic development of all animal species, in the regeneration of tissues in adult organisms and in many other processes. Mutations or deregulated expression of components of the Wnt pathway can induce disease, most importantly cancer. The first gene to be identified that encodes a Wnt signalling component, Int1 (integration 1), was molecularly characterized from mouse tumour cells 25 years ago. In parallel, the homologous gene Wingless in Drosophila melanogaster, which produces developmental defects in embryos, was characterized. Since then, further components of the Wnt pathway have been identified and their epistatic relationships have been defined. This article is a Timeline of crucial discoveries about the components and functions of this essential pathway.



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RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
APCHumanaltered Wnt signaling, canonical pathway   TAS  RGD 
AXIN1Humanaltered Wnt signaling, canonical pathway   TAS  RGD 
AXIN2Humanaltered Wnt signaling, canonical pathway   TAS  RGD 
ApcRataltered Wnt signaling, canonical pathway   ISOAPC (Homo sapiens) RGD 
ApcMousealtered Wnt signaling, canonical pathway   ISOAPC (Homo sapiens) RGD 
Axin1Mousealtered Wnt signaling, canonical pathway   ISOAXIN1 (Homo sapiens) RGD 
Axin1Rataltered Wnt signaling, canonical pathway   ISOAXIN1 (Homo sapiens) RGD 
Axin2Mousealtered Wnt signaling, canonical pathway   ISOAXIN2 (Homo sapiens) RGD 
Axin2Rataltered Wnt signaling, canonical pathway   ISOAXIN2 (Homo sapiens) RGD 
CTNNB1Humanaltered Wnt signaling, canonical pathway   TAS  RGD 
Ctnnb1Mousealtered Wnt signaling, canonical pathway   ISOCTNNB1 (Homo sapiens) RGD 
Ctnnb1Rataltered Wnt signaling, canonical pathway   ISOCTNNB1 (Homo sapiens) RGD 
LRP5Humanaltered Wnt signaling, canonical pathway   TAS  RGD 
Lrp5Mousealtered Wnt signaling, canonical pathway   ISOLRP5 (Homo sapiens) RGD 
Lrp5Rataltered Wnt signaling, canonical pathway   ISOLRP5 (Homo sapiens) RGD 
APCHumancolorectal cancer pathway   TAS  RGD 
AXIN1Humancolorectal cancer pathway   TAS  RGD 
AXIN2Humancolorectal cancer pathway   TAS  RGD 
ApcRatcolorectal cancer pathway   ISOHspb8 (Mus musculus) RGD 
ApcMousecolorectal cancer pathway   ISOHspb8 (Mus musculus) RGD 
Axin1Mousecolorectal cancer pathway   ISOAXIN1 (Homo sapiens) RGD 
Axin1Ratcolorectal cancer pathway   ISOAXIN1 (Homo sapiens) RGD 
Axin2Mousecolorectal cancer pathway   ISOAXIN2 (Homo sapiens) RGD 
Axin2Ratcolorectal cancer pathway   ISOAXIN2 (Homo sapiens) RGD 
CTNNB1Humancolorectal cancer pathway   TAS  RGD 
Ctnnb1Mousecolorectal cancer pathway   ISOCTNNB1 (Homo sapiens) RGD 
Ctnnb1Ratcolorectal cancer pathway   ISOCTNNB1 (Homo sapiens) RGD 
APCHumanWnt signaling, canonical pathway   TAS  RGD 
AXIN1HumanWnt signaling, canonical pathway   TAS  RGD 
AXIN2HumanWnt signaling, canonical pathway   TAS  RGD 
ApcRatWnt signaling, canonical pathway   ISOAPC (Homo sapiens) RGD 
ApcMouseWnt signaling, canonical pathway   ISOAPC (Homo sapiens) RGD 
Axin1MouseWnt signaling, canonical pathway   ISOAXIN1 (Homo sapiens) RGD 
Axin1RatWnt signaling, canonical pathway   ISOAXIN1 (Homo sapiens) RGD 
Axin2MouseWnt signaling, canonical pathway   ISOAXIN2 (Homo sapiens) RGD 
Axin2RatWnt signaling, canonical pathway   ISOAXIN2 (Homo sapiens) RGD 
BTRCHumanWnt signaling, canonical pathway   TAS  RGD 
BtrcRatWnt signaling, canonical pathway   ISOBTRC (Homo sapiens) RGD 
BtrcMouseWnt signaling, canonical pathway   ISOBTRC (Homo sapiens) RGD 
CSNK1A1HumanWnt signaling, canonical pathway   TAS  RGD 
CSNK1G1HumanWnt signaling, canonical pathway   TAS  RGD 
CTNNB1HumanWnt signaling, canonical pathway   TAS  RGD 
Csnk1a1RatWnt signaling, canonical pathway   ISOCSNK1A1 (Homo sapiens) RGD 
Csnk1a1MouseWnt signaling, canonical pathway   ISOCSNK1A1 (Homo sapiens) RGD 
Csnk1g1RatWnt signaling, canonical pathway   ISOCSNK1G1 (Homo sapiens) RGD 
Csnk1g1MouseWnt signaling, canonical pathway   ISOCSNK1G1 (Homo sapiens) RGD 
Ctnnb1MouseWnt signaling, canonical pathway   ISOCTNNB1 (Homo sapiens) RGD 
Ctnnb1RatWnt signaling, canonical pathway   ISOCTNNB1 (Homo sapiens) RGD 
DKK1HumanWnt signaling, canonical pathway   ISODkk1 (Mus musculus) RGD 
Dkk1RatWnt signaling, canonical pathway   ISODkk1 (Mus musculus) RGD 
Dkk1MouseWnt signaling, canonical pathway   TAS  RGD 
GSK3BHumanWnt signaling, canonical pathway   TAS  RGD 
Gsk3bRatWnt signaling, canonical pathway   ISOGSK3B (Homo sapiens) RGD 
Gsk3bMouseWnt signaling, canonical pathway   ISOGSK3B (Homo sapiens) RGD 
LEF1HumanWnt signaling, canonical pathway   TAS  RGD 
LRP5HumanWnt signaling, canonical pathway   TAS  RGD 
LRP6HumanWnt signaling, canonical pathway   TAS  RGD 
Lef1RatWnt signaling, canonical pathway   ISOLEF1 (Homo sapiens) RGD 
Lef1MouseWnt signaling, canonical pathway   ISOLEF1 (Homo sapiens) RGD 
Lrp5RatWnt signaling, canonical pathway   ISOLRP5 (Homo sapiens) RGD 
Lrp5MouseWnt signaling, canonical pathway   ISOLRP5 (Homo sapiens) RGD 
Lrp6RatWnt signaling, canonical pathway   ISOLRP6 (Homo sapiens) RGD 
Lrp6MouseWnt signaling, canonical pathway   ISOLRP6 (Homo sapiens) RGD 
WIF1HumanWnt signaling, canonical pathway   TAS  RGD 
Wif1RatWnt signaling, canonical pathway   ISOWIF1 (Homo sapiens) RGD 
Wif1MouseWnt signaling, canonical pathway   ISOWIF1 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Apc  (APC regulator of WNT signaling pathway)
Axin1  (axin 1)
Axin2  (axin 2)
Btrc  (beta-transducin repeat containing E3 ubiquitin protein ligase)
Csnk1a1  (casein kinase 1, alpha 1)
Csnk1g1  (casein kinase 1, gamma 1)
Ctnnb1  (catenin beta 1)
Dkk1  (dickkopf WNT signaling pathway inhibitor 1)
Gsk3b  (glycogen synthase kinase 3 beta)
Lef1  (lymphoid enhancer binding factor 1)
Lrp5  (LDL receptor related protein 5)
Lrp6  (LDL receptor related protein 6)
Wif1  (Wnt inhibitory factor 1)

Genes (Mus musculus)
Apc  (APC, WNT signaling pathway regulator)
Axin1  (axin 1)
Axin2  (axin 2)
Btrc  (beta-transducin repeat containing protein)
Csnk1a1  (casein kinase 1, alpha 1)
Csnk1g1  (casein kinase 1, gamma 1)
Ctnnb1  (catenin beta 1)
Dkk1  (dickkopf WNT signaling pathway inhibitor 1)
Gsk3b  (glycogen synthase kinase 3 beta)
Lef1  (lymphoid enhancer binding factor 1)
Lrp5  (low density lipoprotein receptor-related protein 5)
Lrp6  (low density lipoprotein receptor-related protein 6)
Wif1  (Wnt inhibitory factor 1)

Genes (Homo sapiens)
APC  (APC regulator of WNT signaling pathway)
AXIN1  (axin 1)
AXIN2  (axin 2)
BTRC  (beta-transducin repeat containing E3 ubiquitin protein ligase)
CSNK1A1  (casein kinase 1 alpha 1)
CSNK1G1  (casein kinase 1 gamma 1)
CTNNB1  (catenin beta 1)
DKK1  (dickkopf WNT signaling pathway inhibitor 1)
GSK3B  (glycogen synthase kinase 3 beta)
LEF1  (lymphoid enhancer binding factor 1)
LRP5  (LDL receptor related protein 5)
LRP6  (LDL receptor related protein 6)
WIF1  (WNT inhibitory factor 1)

Objects referenced in this article
Gene HNF1A HNF1 homeobox A Homo sapiens
Gene Hnf1a HNF1 homeobox A Mus musculus
Gene Hnf1a HNF1 homeobox A Rattus norvegicus

Additional Information