RGD Reference Report - Submegabase resolution of epistatically interacting quantitative trait loci for blood pressure applicable for essential hypertension. - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Submegabase resolution of epistatically interacting quantitative trait loci for blood pressure applicable for essential hypertension.

Authors: Chauvet, C  Charron, S  Menard, A  Xiao, C  Roy, J  Deng, AY 
Citation: Chauvet C, etal., J Hypertens. 2008 May;26(5):893-901.
RGD ID: 2292238
Pubmed: PMID:18398331   (View Abstract at PubMed)
DOI: DOI:10.1097/HJH.0b013e3282f85ded   (Journal Full-text)

OBJECTIVE: Although genetic mapping of quantitative trait loci for blood pressure to large chromosome segments is readily achievable, their final identification confronts formidable hurdles. Restriction of the genes lodging in one quantitative trait locus interval to experimental limitation can facilitate their positional cloning. We previously delineated several quantitative trait loci for blood pressure on chromosome 10 of Dahl salt-sensitive rats, but their chromosome delimitations were either large or not definitive. METHODS: In this study, we systematically and comprehensively constructed congenic strains with submegabase (Mb) genome resolution and analyzed their blood pressure by telemetry. RESULTS: Three quantitative trait loci have been conclusively delimited by three congenic strains, each independently lowering the blood pressure. Their intervals are demarcated by genomic regions between 350 and 910 kilobases (kb) in size. Two of the three quantitative trait loci share an epistatic relationship and are separated from one another by less than 170 kb. Two additional quantitative trait loci for blood pressure were also tentatively delineated and their intervals range from 520 kb to 1.75 Mb. Possible genes dwelling in each quantitative trait locus-interval number between 11 and 17. None of these genes is known to exert a functional impact on blood pressure. Work is underway to find candidate genes with mutations that could be responsible for the blood pressure effect. CONCLUSION: Novel diagnostic, prognostic, preventive and/or therapeutic targets for essential hypertension and hypertension-associated diseases are likely to emerge from the identification of these quantitative trait loci. Potential applications of these quantitative trait loci to humans are suggested from the positive results from several association studies, demonstrating the existence of quantitative trait loci in the broad homologous regions.



Disease Annotations    
Hypotension  (IAGP)

Phenotype Annotations    

Mammalian Phenotype

Objects Annotated

QTLs
Bp308  (Blood pressure QTL 308)
Bp309  (Blood pressure QTL 309)
Bp310  (Blood pressure QTL 310)
Bp311  (Blood pressure QTL 311)
Bp312  (Blood pressure QTL 312)

Objects referenced in this article
QTL Bp279 Blood pressure QTL 279 Rattus norvegicus
QTL Bp280 Blood pressure QTL 280 Rattus norvegicus
QTL Bp281 Blood pressure QTL 281 Rattus norvegicus
QTL Bp282 Blood pressure QTL 282 Rattus norvegicus
Strain SS.LEW-(D10Chm128-D10Chm121)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Chm128-D10Chm169)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Chm224-D10Chm222)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Mco30-D10Got92)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Rat17-D10Mgh1)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Rat204-D10Rat9)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Rat24-Igfbp4)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Rat27-Igfbp4)/Ayd null Rattus norvegicus

Additional Information