RGD Reference Report - Synthesis of alpha-fetoprotein and some other serum proteins in testicular tumors. - Rat Genome Database

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Synthesis of alpha-fetoprotein and some other serum proteins in testicular tumors.

Authors: Sakashita, S  Nishi, S  Hirai, H  Tsuji, I 
Citation: Sakashita S, etal., Invest Urol. 1977 Jul;15(1):2-4.
RGD ID: 2292041
Pubmed: PMID:68943   (View Abstract at PubMed)

Serum levels of alpha-fetoprotein were determined in 33 patients with testicular germ cell tumors and were normal in 11 patients with seminoma and in one patient with matured teratoma; high levels were observed in 19 of 21 patients with embryonal carcinoma, teratocarcinoma, or a mixed type of these germ cell tumors. Tissues from the testicular germ cell tumors were cultivated with 14C-labeled leucine. After incubation, the culture media were subjected to immunoelectrophoretic and autoradiographic analyses. The results were: (i) Radioactive alpha-fetoprotein, albumin, transferrin, and alpha1-globulin appeared in the culture media of embryonal carcinomas obtained from two infants. (ii) Radioactive albumin and alpha1-globulin appeared in the culture media of a mixed type tumor metastasized from testis to retroperitoneal region. (iii) No such radioactive proteins appeared in the culture media of primary seminomas.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AFPHumanembryonal carcinoma  IEP protein:increased expression:serumRGD 
AfpRatembryonal carcinoma  ISOAFP (Homo sapiens)protein:increased expression:serumRGD 
AfpMouseembryonal carcinoma  ISOAFP (Homo sapiens)protein:increased expression:serumRGD 
AFPHumanteratocarcinoma  IEP protein:increased expression:serumRGD 
AfpRatteratocarcinoma  ISOAFP (Homo sapiens)protein:increased expression:serumRGD 
AfpMouseteratocarcinoma  ISOAFP (Homo sapiens)protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Afp  (alpha-fetoprotein)

Genes (Mus musculus)
Afp  (alpha fetoprotein)

Genes (Homo sapiens)
AFP  (alpha fetoprotein)


Additional Information