RGD Reference Report - Bone morphogenetic protein-6 is expressed early by activated astrocytes in lesions of rat traumatic brain injury. - Rat Genome Database

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Bone morphogenetic protein-6 is expressed early by activated astrocytes in lesions of rat traumatic brain injury.

Authors: Zhang, Z  Trautmann, K  Artelt, M  Burnet, M  Schluesener, HJ 
Citation: Zhang Z, etal., Neuroscience. 2006;138(1):47-53. Epub 2006 Jan 4.
RGD ID: 2289020
Pubmed: PMID:16388909   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuroscience.2005.11.036   (Journal Full-text)

We have analyzed early expression of bone morphogenetic protein-6 in rat brains subjected to traumatic brain injury. Bone morphogenetic protein-6 was expressed in neurons of the hippocampus and cortex in normal adult rat brains. A pronounced expression of bone morphogenetic protein-6 in astroglia located to the lesion became obvious 48 h postinjury. Bone morphogenetic protein-6(+) glia were distributed around the lesion, thus demarcating the injured tissue from normal brain. Double labeling by immunohistochemistry revealed that the major glial sources for bone morphogenetic protein-6 were reactive astrocytes and few ED1(+) or W3/13(+) cells co-expressed bone morphogenetic protein-6. Furthermore, bone morphogenetic protein-6 expression in neurons located to hippocampus and cortex of the lesioned hemisphere was up-regulated 3 days postinjury. In conclusion, this is the first description of bone morphogenetic protein-6 expression in traumatic brains. Our data suggest that bone morphogenetic protein-6 might be involved in astrogliosis and neuron protection following traumatic brain injury.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BMP6HumanBrain Injuries  ISOBmp6 (Rattus norvegicus)protein:increased expression:brain more ...RGD 
Bmp6RatBrain Injuries  IEP protein:increased expression:brain more ...RGD 
Bmp6MouseBrain Injuries  ISOBmp6 (Rattus norvegicus)protein:increased expression:brain more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bmp6  (bone morphogenetic protein 6)

Genes (Mus musculus)
Bmp6  (bone morphogenetic protein 6)

Genes (Homo sapiens)
BMP6  (bone morphogenetic protein 6)


Additional Information