RGD Reference Report - Comparison of the transcriptional landscapes between human and mouse tissues. - Rat Genome Database

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Comparison of the transcriptional landscapes between human and mouse tissues.

Authors: Lin, Shin  Lin, Yiing  Nery, Joseph R  Urich, Mark A  Breschi, Alessandra  Davis, Carrie A  Dobin, Alexander  Zaleski, Christopher  Beer, Michael A  Chapman, William C  Gingeras, Thomas R  Ecker, Joseph R  Snyder, Michael P 
Citation: Lin S, etal., Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17224-9. doi: 10.1073/pnas.1413624111. Epub 2014 Nov 20.
RGD ID: 18182916
Pubmed: PMID:25413365   (View Abstract at PubMed)
PMCID: PMC4260565   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.1413624111   (Journal Full-text)

Although the similarities between humans and mice are typically highlighted, morphologically and genetically, there are many differences. To better understand these two species on a molecular level, we performed a comparison of the expression profiles of 15 tissues by deep RNA sequencing and examined the similarities and differences in the transcriptome for both protein-coding and -noncoding transcripts. Although commonalities are evident in the expression of tissue-specific genes between the two species, the expression for many sets of genes was found to be more similar in different tissues within the same species than between species. These findings were further corroborated by associated epigenetic histone mark analyses. We also find that many noncoding transcripts are expressed at a low level and are not detectable at appreciable levels across individuals. Moreover, the majority lack obvious sequence homologs between species, even when we restrict our attention to those which are most highly reproducible across biological replicates. Overall, our results indicate that there is considerable RNA expression diversity between humans and mice, well beyond what was described previously, likely reflecting the fundamental physiological differences between these two organisms.




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