RGD Reference Report - Cross-Talk of Expression Quantitative Trait Loci Within 2 Interacting Blood Pressure Quantitative Trait Loci. - Rat Genome Database

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Cross-Talk of Expression Quantitative Trait Loci Within 2 Interacting Blood Pressure Quantitative Trait Loci.

Authors: Lee, NH  Haas, BJ  Letwin, NE  Frank, BC  Luu, TV  Sun, Q  House, CD  Yerga-Woolwine, S  Farms, P  Manickavasagam, E  Joe, B 
Citation: Lee NH, etal., Hypertension. 2007 Oct 15;.
RGD ID: 1643012
Pubmed: PMID:17938377   (View Abstract at PubMed)
DOI: DOI:10.1161/HYPERTENSIONAHA.107.093138   (Journal Full-text)

Genetic dissection of the S rat genome has provided strong evidence for the presence of 2 interacting blood pressure quantitative trait loci (QTLs), termed QTL1 and QTL2, on rat chromosome 5. However, the identities of the underlying interacting genetic factors remain unknown. Further experiments targeted to identify the interacting genetic factors by the substitution mapping approach alone are difficult because of the interdependency of natural recombinations to occur at the 2 QTLs. We hypothesized that the interacting genetic factors underlying these 2 QTLs may interact at the level of gene transcription and thereby represent expression QTLs or eQTLs. To detect these interacting expression QTLs, a custom QTL chip containing the annotated genes within QTL1 and QTL2 was developed and used to conduct a transcriptional profiling study of S and 2 congenic strains that retain either 1 or both of the QTLs. The results uncovered an interaction between 2 transcription factor genes, Dmrta2 and Nfia. Furthermore, the "biological signature" elicited by these 2 transcription factors was differential between the congenic strain that retained Lewis alleles at both QTL1 and QTL2 compared with the congenic strain that retained Lewis alleles at QTL1 alone. A network of transcription factors potentially affecting blood pressure could be traced, lending support to our hypothesis.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SS.LEW-(D5Mco34-D5Rat108)/JrRatdecreased mean systemic arterial blood pressure  IAGP compared to SS/JrRGD 
Objects Annotated

Objects referenced in this article
QTL Bp156 Blood pressure QTL 156 Rattus norvegicus
QTL Bp157 Blood pressure QTL 157 Rattus norvegicus
Strain SS.LEW-(D5Rat54-D5Rat108)/Jr null Rattus norvegicus
Strain SS.LEW-(D5Uia8-D5Rat108)/Jr null Rattus norvegicus
Strain SS.LEW-(D5Uwm14-D5Uwm31)/Jr null Rattus norvegicus

Additional Information