RGD Reference Report - Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat. - Rat Genome Database

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Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat.

Authors: Kose, H  Bando, Y  Izumi, K  Yamada, T  Matsumoto, K 
Citation: Kose H, etal., Mamm Genome. 2007 Aug;18(8):609-15. Epub 2007 Aug 21.
RGD ID: 1643009
Pubmed: PMID:17710484   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-007-9031-7   (Journal Full-text)

Glucose homeostasis is believed to be regulated by multiple genetic components, in addition to numerous external factors. It is therefore crucial to dissect and understand what roles each causative gene plays in maintaining proper glucose metabolism. In OLETF (Otsuka Long-Evans Tokushima Fatty) rat, a model of polygenic type 2 diabetes, at least 14 quantitative trait loci (QTLs) influencing plasma glucose levels were identified. In congenic strains some of the OLETF allelic variants were shown to increase glucose levels. In this study the focus was on two of the hyperglycemic loci, Nidd1/of and Nidd2/of. Congenic rats possessing OLETF genome fragment at either locus showed similar levels of mild hyperglycemia. A newly established double congenic rat showed a further aggravation of hyperglycemia. The Nidd1/of locus was also shown to function in the reduction of plasma leptin levels and fat weights, while the Nidd2/of locus led to increased plasma insulin and fat weights. Interestingly, both plasma leptin and fat weights reverted to the control levels in the double congenic rat. These results indicate that there is an epistatic interaction between the two loci. However, it is unlikely that the abnormal level of enhanced glucose homeostasis is mediated, at least not directly, by leptin or fat mass.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F344.OLETF-(D7Mgh16-D7Mgh20)/TjRatdecreased body weight  IAGP compared to F344/SlcRGD 
F344.OLETF-(D7Mgh16-D7Mgh20)/TjRatdecreased circulating leptin level  IAGP compared to F344/SlcRGD 
F344.OLETF-(D7Mgh16-D7Mgh20)/TjRatdecreased epididymal fat pad weight  IAGP compared to F344/SlcRGD 
F344.OLETF-(D7Rat18-D7Mit2)(D14Rat23-D14Rat12)/TjRatdecreased epididymal fat pad weight  IAGP compared to F344/SlcRGD 
F344.OLETF-(D7Mgh16-D7Mgh20)/TjRatdecreased food intake  IAGP compared to F344/SlcRGD 
F344.OLETF-(D7Mgh16-D7Mgh20)/TjRatdecreased mesenteric fat pad weight inducedIAGP compared to F344/SlcRGD 
F344.OLETF-(D7Mgh16-D7Mgh20)/TjRatdecreased retroperitoneal fat pad weight inducedIAGP compared to F344/SlcRGD 
F344.OLETF-(D7Mgh16-D7Mgh20)/TjRatimpaired glucose tolerance inducedIAGPglucose solutioncompared to F344/SlcRGD 
F344.OLETF-(D7Rat18-D7Mit2)(D14Rat23-D14Rat12)/TjRatimpaired glucose tolerance inducedIAGPglucose solutioncompared to F344/SlcRGD 
F344.OLETF-(D14Rat23-D14Rat12)/TjRatincreased body weight  IAGP compared to F344/SlcRGD 
F344.OLETF-(D7Rat18-D7Mit2)(D14Rat23-D14Rat12)/TjRatincreased body weight  IAGP compared to F344/SlcRGD 
F344.OLETF-(D14Rat23-D14Rat12)/TjRatincreased circulating insulin level inducedIAGPglucose solutioncompared to F344/SlcRGD 
F344.OLETF-(D7Rat18-D7Mit2)(D14Rat23-D14Rat12)/TjRatincreased circulating insulin level inducedIAGPglucose solution RGD 
F344.OLETF-(D7Rat18-D7Mit2)(D14Rat23-D14Rat12)/TjRatincreased food intake  IAGP compared to F344/SlcRGD 
F344.OLETF-(D14Rat23-D14Rat12)/TjRatincreased mesenteric fat pad weight  IAGP compared to F344/SlcRGD 
F344.OLETF-(D14Rat23-D14Rat12)/TjRatincreased retroperitoneal fat pad weight  IAGP compared to F344/SlcRGD 

Objects referenced in this article
QTL Niddm19 Non-insulin dependent diabetes mellitus QTL 19 Rattus norvegicus
QTL Niddm20 Non-insulin dependent diabetes mellitus QTL 20 Rattus norvegicus

Additional Information