RGD Reference Report - Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis. - Rat Genome Database

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Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis.

Authors: Zhang, Z  Fauser, U  Schluesener, HJ 
Citation: Zhang Z, etal., J Cell Mol Med. 2007 Jan-Feb;11(1):111-9.
RGD ID: 1642966
Pubmed: PMID:17367505   (View Abstract at PubMed)
PMCID: PMC4401224   (View Article at PubMed Central)
DOI: DOI:10.1111/j.1582-4934.2007.00004.x   (Journal Full-text)

RhoA is one of the best-studied members of Rho GTPases. Experimental autoimmune neuritis (EAN), which is characterized by infiltration of T cells and macrophages into the peripheral nervous system, is an autoantigen-specific T-cell-mediated animal model of human Guillain-Barre Syndrome. In this study, RhoA expression has been investigated in the dorsal/ventral roots of EAN rats by immunohistochemistry. A significant accumulation of RhoA+ cells was observed on Day 12, with a maximum around Day 15, correlating to the clinical severity of EAN. In dorsal/ventral roots of EAN, RhoA+ cells were seen in perivascular areas but also in the parenchyma. Furthermore, double-labelling experiments showed that the major cellular sources of RhoA were reactive macrophages and T cells. In conclusion, this is the first demonstration of the presence of RhoA in the dorsal/ventral roots of EAN. The time courses and cellular sources of RhoA together with the functions of RhoA indicate that RhoA may function to facilitate macrophage and T-cell infiltration in EAN and therefore could be a potential therapeutic target.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Neuritis  ISORhoa (Rattus norvegicus)1642966; 1642966protein:increased expression:spinal ganglion more ...RGD 
Experimental Autoimmune Neuritis  IEP 1642966protein:increased expression:spinal ganglion more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rhoa  (ras homolog family member A)

Genes (Mus musculus)
Rhoa  (ras homolog family member A)

Genes (Homo sapiens)
RHOA  (ras homolog family member A)

Additional Information