RGD Reference Report - Increased insulin sensitivity and reduced micro and macro vascular disease induced by 2-deoxy-D-glucose during metabolic syndrome in obese JCR: LA-cp rats. - Rat Genome Database

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Increased insulin sensitivity and reduced micro and macro vascular disease induced by 2-deoxy-D-glucose during metabolic syndrome in obese JCR: LA-cp rats.

Authors: Russell, JC  Proctor, SD 
Citation: Russell JC and Proctor SD, Br J Pharmacol. 2007 May;151(2):216-25. Epub 2007 Mar 20.
RGD ID: 1642389
Pubmed: PMID:17375078   (View Abstract at PubMed)
PMCID: PMC2013948   (View Article at PubMed Central)
DOI: DOI:10.1038/sj.bjp.0707226   (Journal Full-text)

BACKGROUND AND PURPOSE: The metabolic syndrome, characterized by obesity, insulin resistance and dyslipidemia, is a major cause of cardiovascular disease. The origins of the syndrome have been hypothesized to lie in continuous availability of energy dense foods in modern societies. In contrast, human physiology has evolved in an environment of sporadic food supply and frequent food deprivation. Intermittent food restriction in rats has previously been shown to lead to reduction of cardiovascular risk and a greater life span. The non-metabolizable glucose analogue, 2-deoxy-D-glucose (2-DG) is taken up by cells and induces pharmacological inhibition of metabolism of glucose. We hypothesized that intermittent inhibition of glucose metabolism, a metabolic deprivation, may mimic intermittent food deprivation and ameliorate metabolic and pathophysiological aspects of the metabolic syndrome. EXPERIMENTAL APPROACH: Insulin resistant, atherosclerosis-prone JCR:LA-cp rats were treated with 2-DG (0.3% w/w in chow) on an intermittent schedule (2 days treated, one day non-treated, two days treated and two days non-treated) or continuously at a dose to give an equivalent averaged intake. KEY RESULTS: Intermittent 2-DG-treatment improved insulin sensitivity, which correlated with increased adiponectin concentrations. Further, intermittent treatment (but not continuous treatment) reduced plasma levels of leptin and the inflammatory cytokine IL-1 beta. Both 2-DG treatments reduced micro-vascular glomerular sclerosis, but only the intermittent schedule improved macro-vascular dysfunction. CONCLUSIONS AND IMPLICATIONS: Our findings are consistent with reduction in severity of the metabolic syndrome and protection against end stage micro- and macro-vascular disease through intermittent metabolic deprivation at a cellular level by inhibition of glucose oxidation with 2-DG.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LA-cp/NJcrRatcardiovascular system disease  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatfocal segmental glomerulosclerosis  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatHyperphagia  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatMetabolic Syndrome  IAGP compared to lean LA/NJcr+/+ ratsRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LA-cp/NJcrRatalbuminuria  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatglomerulosclerosis  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRathyperlipidemia  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased body weight  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased circulating cholesterol level  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased circulating HDL cholesterol level  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased circulating insulin level  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased circulating interleukin-1 beta level  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased circulating LDL cholesterol level  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased circulating triglyceride level  IAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased food intake  IAGP compared to lean LA/NJcr+/+ ratsRGD 
Objects Annotated

Strains
LA-cp/NJcr  (NA)


Additional Information