RGD Reference Report - Tissue kallikrein and bradykinin B2 receptors in the reproductive tract of the male rat. - Rat Genome Database

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Tissue kallikrein and bradykinin B2 receptors in the reproductive tract of the male rat.

Authors: Monsees, TK  Blocher, S  Loddo, C  Steger, K  Schill, WB 
Citation: Monsees TK, etal., Andrologia. 2003 Feb;35(1):24-31.
RGD ID: 1641807
Pubmed: PMID:12558526   (View Abstract at PubMed)

The setting of a local tissue kallikrein kinin system (tKKS) within the reproductive organs of the male rat was investigated by analysing bradykinin subtype 2 receptor (B2R) gene expression and cellular distribution of B2R protein and the kinin-liberating protease tissue kallikrein (tK). Reverse transcription-polymerase chain reaction showed B2R expression in testis, epididymis and prostate from prepubertal and sexually mature rats. In mature testis, in situ hybridization and immunohistochemistry localized B2R mRNA and protein besides endothelial cells of blood vessels exclusively on pachytene spermatocytes and round and elongated spermatids. B2R expression within the seminiferous tubules was found to be dependent on the stage of the spermatogenic cycle. In pre-pubertal rat testis, B2R mRNA and protein were additionally located in peritubular cells. In the testis, specific staining for tK occurred in addition to endothelial cells of blood vessels on the acrosomal cap of round and elongated spermatids. This immunostaining was also stage-dependent. In the epididymis, tK was detected on epithelial cells near the apical surface. The stage-dependent specific expression of tK and bradykinin B2Rs in developing germ cells and peritubular cells suggests a potential role of the tKKS in the local regulation of spermatogenesis and seminiferous tubule function.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Klk1Ratacrosomal vesicle  IDA  RGD 
Klk1Ratapical part of cell  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Klk1  (kallikrein 1)

Objects referenced in this article
Gene Klk1c12 kallikrein 1-related peptidase C12 Rattus norvegicus

Additional Information