RGD Reference Report - Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. - Rat Genome Database

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Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study.

Authors: Karamohamed, S  Demissie, S  Volcjak, J  Liu, C  Heard-Costa, N  Liu, J  Shoemaker, CM  Panhuysen, CI  Meigs, JB  Wilson, P  Atwood, LD  Cupples, LA  Herbert, A  Herbert, Alan 
Citation: Karamohamed S, etal., Diabetes. 2003 Jun;52(6):1562-7.
RGD ID: 1626697
Pubmed: PMID:12765971   (View Abstract at PubMed)

Linkage studies have mapped a susceptibility gene for type 2 diabetes to the long arm of chromosome 10, where we have previously identified a quantitative trait locus that affects fasting blood glucose within the Framingham Heart Study cohort. One candidate gene in this region is the insulin-degrading enzyme (IDE), which, in the GK rat model, has been associated with nonobese type 2 diabetes. Single nucleotide polymorphisms (SNPs) were used to map a haplotype block in the 3' end of IDE, which revealed association with HbA(1c), fasting plasma glucose (FPG), and mean fasting plasma glucose (mFPG) measured over 20 years. The strongest associations were found in a sample of unrelated men. The lowest trait values were associated with a haplotype (TT, f approximately 0.32) containing the minor allele of rs2209772 and the major allele of the rs1887922 SNP (FPG P < 0.001, mFPG P < 0.003, HbA(1c) P < 0.025). Another haplotype (CC, f approximately 0.16) was associated with elevated HbA(1c) (P < 0.002) and type 2 diabetes (P < 0.001, odds ratio 1.96, 95% CI 1.28-3.00). The evidence presented supports the possibility that IDE is a susceptibility gene for diabetes in populations of European descent.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  IAGP 1626697DNA:haplotype::CC haplotype of SNPs rs2209972 and rs1887922 in men of European descent from the Framingham Heart StudyRGD 
type 2 diabetes mellitus  ISOIDE (Homo sapiens)1626697; 1626697DNA:SNPs more ...RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Elevated hemoglobin A1c  IAGP 1626697DNA:SNPs more ...RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ide  (insulin degrading enzyme)

Genes (Mus musculus)
Ide  (insulin degrading enzyme)

Genes (Homo sapiens)
IDE  (insulin degrading enzyme)


Additional Information