RGD Reference Report - AA and ANA rats exhibit the R100Q mutation in the GABAA receptor alpha 6 subunit. - Rat Genome Database

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AA and ANA rats exhibit the R100Q mutation in the GABAA receptor alpha 6 subunit.

Authors: Carr, LG  Spence, JP  Peter Eriksson, CJ  Lumeng, L  Li, TK 
Citation: Carr LG, etal., Alcohol. 2003 Aug-Oct;31(1-2):93-7.
RGD ID: 1626511
Pubmed: PMID:14615016   (View Abstract at PubMed)

The R100Q mutation in the gamma-aminobutyric acid type A (GABA(A)) receptor alpha(6) subunit was previously identified in Sardinian alcohol-preferring (sP) and Sardinian alcohol-nonpreferring (sNP) rats as a candidate gene influencing alcohol preference and sensitivity. The purpose of the current study was to determine to what extent this mutation and alcohol preference observed in the sP and sNP lines was present in other independently selected rat lines, including inbred alcohol-preferring (iP) and inbred alcohol-nonpreferring (iNP), high-alcohol-drinking 1 (HAD1) and low-alcohol-drinking 1 (LAD1), high-alcohol-drinking 2 (HAD2) and low-alcohol-drinking 2 (LAD2), and Alko Alcohol (AA) and Alko Non-Alcohol (ANA). Sequence analysis was first performed to screen for the R100Q mutation in several samples. Later, a genotyping assay was conducted to assess the frequency of the R100Q mutation in larger sample sizes. The R100Q mutation was identified only in the AA/ANA population, with a significantly (P<.0001) higher frequency in the alcohol-nonpreferring ANA line. The absence of the R100Q mutation in the other rat lines that were selectively bred for alcohol consumption and alcohol preference may be due to genetic diversity among the Wistar stocks used to develop the various lines.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gabra6Ratalcohol preference  IAGP DNA:polymorphism:CDS:amino acid R100Q and Q allele higher in the alcohol preferring ANA line than the AA non-preferring line P<0.0001RGD 
Objects Annotated

Genes (Rattus norvegicus)
Gabra6  (gamma-aminobutyric acid type A receptor subunit alpha6)


Additional Information