RGD Reference Report - Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats. - Rat Genome Database

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Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats.

Authors: Beylot, M  Pinteur, C  Peroni, O 
Citation: Beylot M, etal., Metabolism. 2006 Mar;55(3):396-401.
RGD ID: 1625763
Pubmed: PMID:16483885   (View Abstract at PubMed)
DOI: DOI:10.1016/j.metabol.2005.09.016   (Journal Full-text)

The adiponectin receptors, AdipoR1 and AdipoR2, are thought to transmit the insulin-sensitizing effects of adiponectin, an adipokine secreted by adipocytes. Modifications of their expression in insulin-sensitive tissues (skeletal muscle, liver, and adipose tissue) could therefore play a role in the control of insulin sensitivity and the development of insulin resistance. Recent data in mice supported this possibility. We examined whether the expression of adiponectin receptors (messenger RNA [mRNA] concentrations) is controlled in vivo in rats (Wistar) by nutritional factors (high-fat [HF] vs high-carbohydrate diet, fasting vs fed state) and whether this expression is decreased in an experimental model of insulin resistance, the obese Zucker rat. In Wistar rats, neither an HF diet nor fasting modified the mRNA concentrations of AdipoR1 in muscle, liver, or adipose tissue; the only modification observed was a decrease (P < .05) in AdipoR2 mRNA level in the liver of rats fed with an HF diet. In obese Zucker rats compared with their lean controls, neither AdipoR1 nor AdipoR2 expression was modified in muscle. AdipoR2 expression was slightly decreased in adipose tissue, whereas the expression of both AdipoR1 and AdipoR2 was increased (P < .05) in the liver of obese Zucker rats. In conclusion, contrary to what was reported in mice, the expression of adiponectin receptors in rats is poorly responsive to changes in nutritional conditions and is not decreased in a model of insulin resistance. These results do not support an important role for the expression of AdipoR1 and AdipoR2 in the modulation of sensitivity to insulin.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADIPOR1Humanobesity  ISOAdipor1 (Rattus norvegicus)mRNA:increased expression:liverRGD 
ADIPOR2Humanobesity  ISOAdipor2 (Rattus norvegicus)mRNA:increased expression:liverRGD 
Adipor1Ratobesity  IEP mRNA:increased expression:liverRGD 
Adipor1Mouseobesity  ISOAdipor1 (Rattus norvegicus)mRNA:increased expression:liverRGD 
Adipor2Ratobesity  IEP mRNA:increased expression:liverRGD 
Adipor2Mouseobesity  ISOAdipor2 (Rattus norvegicus)mRNA:increased expression:liverRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Adipor2Ratresponse to nutrient  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipor1  (adiponectin receptor 1)
Adipor2  (adiponectin receptor 2)

Genes (Mus musculus)
Adipor1  (adiponectin receptor 1)
Adipor2  (adiponectin receptor 2)

Genes (Homo sapiens)
ADIPOR1  (adiponectin receptor 1)
ADIPOR2  (adiponectin receptor 2)


Additional Information